Department of Obstetrics and Gynecology, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi, Hubei, China.
Department of Obstetrics and Gynecology, Jianshi Hospital of Traditional Chinese Medicine, Jianshi, Hubei, China.
J Gynecol Obstet Hum Reprod. 2022 Jun;51(6):102395. doi: 10.1016/j.jogoh.2022.102395. Epub 2022 Apr 28.
Previous studies examining the incidence of omental metastasis in uterine serous carcinoma generally suffered from small sample size, retrospective observational design, and single-center setting. So far, there was no systematic review and meta-analysis available on this topic, we conducted this study to quantitatively synthesize the data relating to this topic.
systematic review and meta-analysis.
PubMed, Embase, and Web of Science were searched up until August 15, 2020. Two reviewers independently performed study selection, data extraction, and quality assessment. I was employed to assess the heterogeneity among the included studies. Effect sizes along with 95% confidence intervals were calculated to analyze outcomes of interest. Funnel plots and the Egger test were used to detect the risk of publication bias.
incidence of omental metastasis in uterine serous carcinoma.
A total of 16 studies involving 1012 women with uterine serous carcinoma were included in this study. All the included studies were at low risk of bias, and the heterogeneity among them was low. The pooled incidence of overall omental metastasis, occult omental metastasis, and gross omental metastasis in uterine serous carcinoma were 18% (95% CI, 0.15-0.20), 6% (95% CI, 0.04-0.08), and 10% (95% CI, 0.08-0.13), respectively.
Uterine serous carcinoma has a high tendency of omental metastasis. The main form of omentum involvement is gross metastasis. However, occult metastasis in the normal-looking omentum is also worthy of note.
既往研究检查了在子宫浆液性癌中网膜转移的发生率，这些研究通常存在样本量小、回顾性观察性设计和单中心设置的问题。迄今为止，尚无关于该主题的系统评价和荟萃分析，因此，我们开展了这项研究以定量综合与该主题相关的数据。
系统评价和荟萃分析。
截至 2020 年 8 月 15 日，我们检索了 PubMed、Embase 和 Web of Science。两名评审员独立进行了研究选择、数据提取和质量评估。我被雇用来评估纳入研究之间的异质性。使用效应大小和 95%置信区间来分析感兴趣的结果。漏斗图和 Egger 检验用于检测发表偏倚的风险。
子宫浆液性癌中网膜转移的发生率。
共有 16 项纳入了 1012 例子宫浆液性癌患者的研究被纳入本研究。所有纳入的研究均存在低偏倚风险，且它们之间的异质性较低。子宫浆液性癌总体网膜转移、隐匿性网膜转移和大体性网膜转移的合并发生率分别为 18%（95%CI，0.15-0.20）、6%（95%CI，0.04-0.08）和 10%（95%CI，0.08-0.13）。
子宫浆液性癌有发生网膜转移的高倾向。网膜受累的主要形式是大体性转移。然而，正常外观的网膜中的隐匿性转移也值得注意。
