Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Division of Colon and Rectal Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
Anticancer Res. 2022 May;42(5):2375-2382. doi: 10.21873/anticanres.15716.
BACKGROUND/AIM: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) is responsible for folate metabolism, and we aimed to investigate its genetic role in colorectal cancer (CRC) among Taiwanese.
A total of 362 cases and 362 controls were recruited and their MTRR rs1801394 (A66G) and rs1532268 (C524T) genotypes were examined. The behavioral factors and clinicalpathological factors were also analyzed.
MTRR rs1801394 genotypes were associated with CRC risk (p for trend=0.0087). In detail, G/G genotype was associated with lower risk (p=0.0049, OR=0.39, 95%CI=0.20-0.76). As for allelic frequency analysis, G allele was also associated with decreased CRC risk (p=0.0026, OR=0.68, 95%CI=0.53-0.88). There was no significant association as for MTRR rs1532268. Among non-smokers and non-alcohol drinkers, those with G/G genotype were at 0.38- and 0.46-fold odds of having CRC. There were no significant protective effects among smokers or alcohol drinkers.
MTRR rs1801394 GG genotype can be a protective marker for CRC risk in Taiwan.
背景/目的：5-甲基四氢叶酸-同型半胱氨酸甲基转移酶还原酶（MTRR）负责叶酸代谢，我们旨在研究其在台湾人群中的遗传作用与结直肠癌（CRC）的关系。
共招募了 362 例病例和 362 例对照，并对其 MTRR rs1801394（A66G）和 rs1532268（C524T）基因型进行了检测。还分析了行为因素和临床病理因素。
MTRR rs1801394 基因型与 CRC 风险相关（趋势检验 p=0.0087）。具体而言，G/G 基因型与较低的风险相关（p=0.0049，OR=0.39，95%CI=0.20-0.76）。对于等位基因频率分析，G 等位基因也与 CRC 风险降低相关（p=0.0026，OR=0.68，95%CI=0.53-0.88）。而对于 MTRR rs1532268 则没有显著相关性。在非吸烟者和非饮酒者中，G/G 基因型患 CRC 的风险分别降低 0.38 倍和 0.46 倍。而在吸烟者或饮酒者中则没有显著的保护作用。
MTRR rs1801394 GG 基因型可能是台湾 CRC 风险的保护性标志物。
