Oral ciprofloxacin in the treatment of uncomplicated gonococcal urethritis in men.

Two hundred and seventy-one male patients suffering from uncomplicated gonococcal urethritis were treated in an open randomized study with either 250 mg (121 patients) or 500 mg (150 patients) single oral doses of ciprofloxacin. The efficacy of treatment was verified on the third day by direct examination of urethral swabs in 91 patients and by culture and direct microscopic examination in 180 subjects. Cure rates were 100% in the 500 mg group and 96.6% in the 250 mg treated patients. No side effects were seen. Ciprofloxacin appears to be a very effective and safe drug in the treatment of uncomplicated gonococcal urethritis in men.