Biosecurity Research Program, The Kirby Institute, UNSW, Sydney, Australia.
School of Medical Science, UNSW, Sydney, Australia.
Int J Cardiol. 2022 Aug 15;361:109-115. doi: 10.1016/j.ijcard.2022.04.069. Epub 2022 Apr 29.
Cardiac arrest is the least preventable burden of cardiovascular disease, as treatment depends on timely resuscitation. The incidence of sudden cardiac arrest (SCA) is high, contributing 10-20% of cardiovascular mortality globally. The influenza vaccine reduces the risk of acute cardiovascular events. Little is known about the relationship of influenza infection to cardiac arrest.
This study aimed to determine the estimated rate of SCA hospitalisations attributable to influenza in Australian adults. A generalised-additive statistical model was applied in the study. Weekly counts of laboratory-confirmed influenza notifications were used as independent variables in the model.
Our estimates showed that the yearly rate of SCA hospitalisations varied, and a significant association with influenza was observed in some years in older adults aged 65 years and over. On average, the annual estimated SCA hospitalisations rate due to influenza in adults aged 50-64 years and ≥ 65 years were 0.7 (95%CI: 0.4, 1.1) and 5.3 (95%CI: 4.4, 6.2) per 100,000 population, respectively.
The association between influenza and SCA is evident in adults and the disease burden is significant in older people. Prevention of influenza by vaccination may reduce SCA.
心脏骤停是心血管疾病中最难以预防的负担，因为治疗取决于及时复苏。全球范围内，突发性心脏骤停（SCA）的发病率较高，占心血管疾病死亡率的 10-20%。流感疫苗可降低急性心血管事件的风险。关于流感感染与心脏骤停之间的关系知之甚少。
本研究旨在确定澳大利亚成年人因流感导致的 SCA 住院的估计发生率。研究采用了广义加性统计模型。模型中的独立变量是实验室确诊的流感报告的每周计数。
我们的估计表明，SCA 住院的年发生率存在差异，在某些年份，65 岁及以上的老年人中观察到与流感有显著关联。平均而言，50-64 岁和≥65 岁成年人因流感导致的年度估计 SCA 住院率分别为每 10 万人 0.7（95%CI：0.4，1.1）和 5.3（95%CI：4.4，6.2）。
流感与 SCA 之间存在关联，在成年人中较为明显，在老年人中疾病负担较大。通过接种疫苗预防流感可能会降低 SCA 的发生率。
