College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China; Chinese PLA Medical School, Beijing, China.
Peking University Clinical Research Institute, Peking University First Hospital, Beijing, China; PUCRI Heart and Vascular Health Research Center at Peking University Shougang Hospital, Beijing, China; Key Laboratory of Molecular Cardiovascular Sciences, Peking University, Ministry of Education, Beijing, China.
J Affect Disord. 2022 Jul 15;309:404-410. doi: 10.1016/j.jad.2022.04.141. Epub 2022 Apr 28.
Little is known about the longitudinal association between persistent depressive symptoms and future lung health in the general population.
4860 middle-aged and older participants with repeated measurements of depressive symptoms at wave 1 (2002-2003) and wave 2 (2004-2005) and at least two measurements of lung function (waves 2-6, 2004-2013) from the English Longitudinal Study of Ageing, were included in this study. The Center for Epidemiologic Studies Depression Scale (CESD) was used to evaluate depressive symptoms. Participants who had depressive symptoms in both waves 1 and 2 were considered to have persistent depressive symptoms. Linear mixed models were applied to assess longitudinal associations. Cox regression models were fitted to analyze respiratory disease mortality.
During an 8-year follow-up, we found that women with persistent depressive symptoms suffered accelerated declines in forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), percentage of the FEV1 predicted, percentage of the FVC predicted, and peak expiratory flow, compared with women without depressive symptoms at baseline. Likewise, an elevated risk of respiratory disease mortality (HR: 6.02, 95% CI: 2.30 to 15.79) was observed in women with persistent depressive symptoms compared with women without depressive symptoms. We also observed a dose-response relationship between cumulative depressive symptom scores and subsequent lung health outcomes in women. However, no such association was observed in men.
Long-term depressive symptoms might predict an accelerated decline of lung function and higher mortality from respiratory disease among women but not among men over an 8-year follow-up. Further studies are needed to verify our findings.
在一般人群中，持续性抑郁症状与未来肺部健康之间的纵向关联知之甚少。
本研究纳入了来自英国老龄化纵向研究的 4860 名中年及以上参与者，这些参与者在第 1 波（2002-2003 年）和第 2 波（2004-2005 年）时重复测量了抑郁症状，并且至少在第 2-6 波（2004-2013 年）时测量了两次肺功能。使用中心流行病学研究抑郁量表（CESD）评估抑郁症状。在第 1 波和第 2 波都有抑郁症状的参与者被认为患有持续性抑郁症状。应用线性混合模型评估纵向关联。拟合 Cox 回归模型分析呼吸疾病死亡率。
在 8 年的随访期间，我们发现与基线时无抑郁症状的女性相比，患有持续性抑郁症状的女性，其 1 秒用力呼气量（FEV1）、用力肺活量（FVC）、FEV1 预计值百分比、FVC 预计值百分比和呼气峰流速的下降速度更快。同样，与无抑郁症状的女性相比，患有持续性抑郁症状的女性发生呼吸疾病死亡的风险更高（HR：6.02，95%CI：2.30 至 15.79）。我们还观察到，女性累积抑郁症状评分与随后的肺部健康结果之间存在剂量-反应关系。然而，在男性中没有观察到这种关联。
在 8 年的随访中，长期的抑郁症状可能预示着女性的肺功能下降加速，呼吸疾病死亡率更高，但在男性中则没有这种关联。需要进一步的研究来验证我们的发现。
