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A "LEAP" forward in understanding immune mechanisms of oral tolerance to peanut.在理解对花生口服耐受的免疫机制方面向前迈出的“一大步”。
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2
A single priming event prevents oral tolerance to peanut.单次致敏事件可预防花生口服耐受。
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Allergen-specific oral immunotherapy for peanut allergy.针对花生过敏的过敏原特异性口服免疫疗法。
Cochrane Database Syst Rev. 2012 Sep 12;2012(9):CD009014. doi: 10.1002/14651858.CD009014.pub2.
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Evolution of epitope-specific IgE and IgG antibodies in children enrolled in the LEAP trial.在 LEAP 试验中入组的儿童中表位特异性 IgE 和 IgG 抗体的演变。
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Epitope-Specific IgE at 1 Year of Age Can Predict Peanut Allergy Status at 5 Years.1 岁时的表位特异性 IgE 可预测 5 岁时的花生过敏状态。
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Current opinion and review on peanut oral immunotherapy.关于花生口服免疫疗法的当前观点与综述
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Randomized, placebo-controlled, phase 1 safety study of oral mucosal immunotherapy in adults with peanut allergy.针对花生过敏成人的口服黏膜免疫疗法的随机、安慰剂对照1期安全性研究。
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Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3).花生口服免疫治疗可导致抗原诱导的调节性 T 细胞功能增强和叉头框蛋白 3（FOXP3）的低甲基化。
J Allergy Clin Immunol. 2014 Feb;133(2):500-10. doi: 10.1016/j.jaci.2013.12.1037.
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A mouse model of the LEAP study reveals a role for CTLA-4 in preventing peanut allergy induced by environmental peanut exposure.一项 LEAP 研究的小鼠模型揭示 CTLA-4 在预防环境花生暴露引起的花生过敏中的作用。
J Allergy Clin Immunol. 2022 Aug;150(2):425-439.e3. doi: 10.1016/j.jaci.2022.02.024. Epub 2022 Mar 12.

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Early introduction is not enough: CSACI statement on the importance of ongoing regular ingestion as a means of food allergy prevention.早期引入并不够：加拿大过敏、哮喘和免疫学会关于持续规律摄入作为预防食物过敏手段的重要性的声明
Allergy Asthma Clin Immunol. 2023 Jul 18;19(1):63. doi: 10.1186/s13223-023-00814-2.

本文引用的文献

1
A mouse model of the LEAP study reveals a role for CTLA-4 in preventing peanut allergy induced by environmental peanut exposure.一项 LEAP 研究的小鼠模型揭示 CTLA-4 在预防环境花生暴露引起的花生过敏中的作用。
J Allergy Clin Immunol. 2022 Aug;150(2):425-439.e3. doi: 10.1016/j.jaci.2022.02.024. Epub 2022 Mar 12.
2
The airway as a route of sensitization to peanut: An update to the dual allergen exposure hypothesis.气道作为花生致敏的途径：双过敏原暴露假说的更新。
J Allergy Clin Immunol. 2021 Sep;148(3):689-693. doi: 10.1016/j.jaci.2021.05.035. Epub 2021 Jun 7.
3
Mechanisms of Oral Tolerance.口服耐受的机制。
Clin Rev Allergy Immunol. 2018 Oct;55(2):107-117. doi: 10.1007/s12016-018-8680-5.
4
Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice.气道暴露通过在小鼠中涉及 IL-1 途径和 T 滤泡辅助细胞引发花生过敏。
J Allergy Clin Immunol. 2018 Oct;142(4):1144-1158.e8. doi: 10.1016/j.jaci.2017.11.020. Epub 2017 Dec 14.
5
Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management.食物过敏：流行病学、发病机制、诊断、预防和管理的综述和更新。
J Allergy Clin Immunol. 2018 Jan;141(1):41-58. doi: 10.1016/j.jaci.2017.11.003. Epub 2017 Nov 21.
6
Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel.美国预防花生过敏补充指南：美国国立过敏与传染病研究所资助的专家小组报告
J Allergy Clin Immunol. 2017 Jan;139(1):29-44. doi: 10.1016/j.jaci.2016.10.010.
7
Effect of Avoidance on Peanut Allergy after Early Peanut Consumption.早期食用花生后回避对花生过敏的影响。
N Engl J Med. 2016 Apr 14;374(15):1435-43. doi: 10.1056/NEJMoa1514209. Epub 2016 Mar 4.
8
Randomized trial of peanut consumption in infants at risk for peanut allergy.对有花生过敏风险婴儿食用花生的随机试验。
N Engl J Med. 2015 Feb 26;372(9):803-13. doi: 10.1056/NEJMoa1414850. Epub 2015 Feb 23.
9
Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria.肠道耐受需要肠道归巢和固有层中 FoxP3+调节性 T 细胞的扩增。
Immunity. 2011 Feb 25;34(2):237-46. doi: 10.1016/j.immuni.2011.01.016. Epub 2011 Feb 17.
10
Oral tolerance in the absence of naturally occurring Tregs.在缺乏天然存在的调节性T细胞的情况下的口服耐受。
J Clin Invest. 2005 Jul;115(7):1923-33. doi: 10.1172/JCI24487. Epub 2005 Jun 2.

A "LEAP" forward in understanding immune mechanisms of oral tolerance to peanut.

作者信息

Moran Timothy P, Kulis Michael D

机构信息

Department of Pediatrics, Division of Allergy and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC.

Department of Pediatrics, Division of Allergy and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC.

出版信息

J Allergy Clin Immunol. 2022 Aug;150(2):299-301. doi: 10.1016/j.jaci.2022.04.022. Epub 2022 Apr 28.

DOI:10.1016/j.jaci.2022.04.022
PMID:35490903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9635268/
Abstract
摘要