Department of Oncology, Fuda Cancer Hospital, Jinan University, Guangzhou, People's Republic of China; Department of Oncology, First Affiliated Hospital of Jinan University, Guangzhou, People's Republic of China.
Department of Oncology, Fuda Cancer Hospital, Jinan University, Guangzhou, People's Republic of China.
J Vasc Interv Radiol. 2022 Aug;33(8):942-948. doi: 10.1016/j.jvir.2022.04.021. Epub 2022 Apr 29.
To assess the safety and efficacy of cryoablation in patients with lung nodules mainly composed of ground-glass opacities (GGOs).
In this retrospective study, 50 patients (mean age, 65.0 years ± 12.3; 28 women) with a diagnosis of lung GGO nodules who underwent cryoablation were included (from June 2016 to June 2021). The local recurrence rate, incidence of regional metastases to lymph nodes, incidence of distant metastases, adverse events, and lung function condition were analyzed.
Follow-up computed tomography (CT) was performed at a mean of 33 months (range, 3-60 months) after the cryoablation procedure. Outcomes were only evaluated in 30 patients. A total of 20 patients were excluded. Of these 20 patients, 10 patients had no cancer detected by histopathological analysis and a diagnosis was made using CT or positron emission tomography (PET)-CT, The other 10 patients had nodules with a diameter of <10 mm and a consolidation-to-tumor ratio of >0.25; thus, histopathological analysis was not performed because of the small nodule size, and patients were diagnosed using CT or PET-CT. The local recurrence rate was 0% (0 of 30). Evidence of regional metastases of lymph nodes was not found in any patients (0%; 0 of 30), and the incidence of distant metastases was 0% (0 of 30). No major adverse events were noted. Lung function recovered to normal within 1 month after cryoablation in all patients.
Cryoablation may serve as a safe and feasible option for the treatment of lung nodules mainly composed of GGOs.
评估主要由磨玻璃密度（GGO）组成的肺结节患者行冷冻消融术的安全性和有效性。
本回顾性研究纳入了 50 例（平均年龄 65.0 岁±12.3 岁；28 例女性）经诊断为肺 GGO 结节并接受冷冻消融术的患者（2016 年 6 月至 2021 年 6 月）。分析局部复发率、区域淋巴结转移率、远处转移率、不良事件和肺功能情况。
冷冻消融术后平均 33 个月（3-60 个月）行随访 CT。仅对 30 例患者的结果进行了评估，排除了 20 例患者。其中 10 例患者经组织病理学分析未发现癌症，诊断为 CT 或正电子发射断层扫描（PET）-CT，另 10 例患者结节直径＜10mm 且实性成分与肿瘤比值＞0.25；因此，由于结节较小，未行组织病理学分析，而是根据 CT 或 PET-CT 进行诊断。30 例患者中，局部复发率为 0%（0/30）。未发现任何患者有区域淋巴结转移证据（0%；0/30），远处转移率为 0%（0/30）。无重大不良事件发生。所有患者在冷冻消融术后 1 个月内肺功能恢复正常。
冷冻消融术可能是一种安全可行的治疗主要由 GGO 组成的肺结节的方法。
