Earle A. Chiles Research Institute in the Robert W. Franz Cancer Center, Providence Cancer Institute, 4805 NE Glisan Street Suite 2N35, Portland, OR 97213, USA.
Earle A. Chiles Research Institute in the Robert W. Franz Cancer Center, Providence Cancer Institute, 4805 NE Glisan Street Suite 2N35, Portland, OR 97213, USA.
Oral Maxillofac Surg Clin North Am. 2022 May;34(2):315-324. doi: 10.1016/j.coms.2021.11.010.
Melanoma is the most common cause of skin cancer-related death in the United States. Cutaneous melanoma is most prevalent in the head and neck. The long-term prognosis has been poor and chemotherapy is not curative. Complete surgical resection with locally advanced disease can be challenging and melanoma is resistant to radiation. Advances made in immunotherapy and genomically targeted therapy have transformed the treatment of metastatic melanoma; as of 2021, the 5-year survival for metastatic melanoma is greater than 50%. Ongoing clinical studies are underway to integrate these life-saving therapies into the presurgical or postsurgical settings. This article reviews that effort.
黑色素瘤是美国导致皮肤癌相关死亡的最常见原因。皮肤黑色素瘤最常见于头部和颈部。长期预后一直较差，化疗无法治愈。局部晚期疾病的完全手术切除可能具有挑战性，且黑色素瘤对辐射具有抗性。免疫疗法和基于基因组的靶向治疗的进展改变了转移性黑色素瘤的治疗方法；截至 2021 年，转移性黑色素瘤的 5 年生存率大于 50%。目前正在进行临床研究，将这些救命疗法纳入术前或术后治疗中。本文综述了这方面的努力。
