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经蝶窦手术治疗老年库欣病患者的高皮质醇血症可改善认知功能和肌肉量

Correction of Hypercortisolemia with an Improved Cognitive Function and Muscle Mass after Transsphenoidal Surgery in an Older Patient with Cushing's Disease.

机构信息

Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Japan.

Department of General Medical Science, Chiba University Graduate School of Medicine, Japan.

出版信息

Intern Med. 2022 Nov 15;61(22):3391-3399. doi: 10.2169/internalmedicine.8326-21. Epub 2022 Apr 30.

DOI:10.2169/internalmedicine.8326-21
PMID:35491128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9751722/
Abstract

Cushing's disease causes numerous metabolic disorders, cognitive decline, and sarcopenia, leading to deterioration of the general health in older individuals. Cushing's disease can be treated with transsphenoidal surgery, but thus far, surgery has often been avoided in older patients. We herein report an older woman with Cushing's disease whose cognitive impairment and sarcopenia improved after transsphenoidal surgery. Although cognitive impairment and sarcopenia in most older patients show resistance to treatment, our case indicates that normalization of the cortisol level by transsphenoidal surgery can be effective in improving the cognitive impairment and muscle mass loss caused by Cushing's disease.

摘要

库欣病可引起多种代谢紊乱、认知功能减退和肌肉减少症，导致老年患者的整体健康状况恶化。库欣病可以通过经蝶窦手术治疗，但迄今为止，老年患者往往避免手术。本文报告了一例库欣病老年女性患者，经蝶窦手术后认知功能障碍和肌肉减少症得到改善。虽然大多数老年患者的认知功能障碍和肌肉减少症对治疗有抵抗作用，但本病例表明，经蝶窦手术使皮质醇水平正常化可有效改善库欣病引起的认知功能障碍和肌肉质量丧失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e3/9751722/1ebc1bf83949/1349-7235-61-3391-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e3/9751722/05f792f1f1cb/1349-7235-61-3391-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e3/9751722/391dceb0b840/1349-7235-61-3391-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e3/9751722/1ebc1bf83949/1349-7235-61-3391-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e3/9751722/05f792f1f1cb/1349-7235-61-3391-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e3/9751722/eb83bca6ec30/1349-7235-61-3391-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e3/9751722/7e0ad74df5e7/1349-7235-61-3391-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e3/9751722/391dceb0b840/1349-7235-61-3391-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e3/9751722/1ebc1bf83949/1349-7235-61-3391-g005.jpg

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