Bin Yan-Lin, Liu Shun-Zhi, Xie Ting-Ting, Feng Wen-Zheng, Li Hao-Yang, Ye Zi-Jia, Dong Zhi-Hao, Qiu Ying-Kun
Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Nat Prod Res. 2023 Oct-Nov;37(19):3276-3282. doi: 10.1080/14786419.2022.2070746. Epub 2022 May 2.
In this study, three new compounds, roxburic acid A () and two flavone glycosides isorhamnetin-3--rhamnosyl-(1→6)--glucopyranose-(1→3)--glucopyranoside (), and kaempferol-7--glucopyranosyl-(1→3)--glucopyranoside () were isolated from an ethanol extract of the fresh (Wall.) Lindl., together with 10 known compounds (). The structures of these compounds were comprehensively characterized by HR-ESI-MS, H NMR, C NMR, and 2 D-NMR. The DPPH free radical scavenging activity of the isolated compounds was evaluated, and the results showed that kaempferol--glucopyranosyl- (1→3) --glucopyranoside () and rutin () has the potential antioxidant activity with IC values of 139 μg/mL and 22.5 μg/mL respectively.
在本研究中，从新鲜的（Wall.）Lindl.的乙醇提取物中分离出三种新化合物，即罗汉果酸A（）以及两种黄酮苷，异鼠李素-3--鼠李糖基-（1→6）--吡喃葡萄糖苷-（1→3）--吡喃葡萄糖苷（）和山柰酚-7--吡喃葡萄糖基-（1→3）--吡喃葡萄糖苷（），同时还分离出10种已知化合物（）。这些化合物的结构通过高分辨电喷雾电离质谱（HR-ESI-MS）、氢核磁共振（H NMR）、碳核磁共振（C NMR）和二维核磁共振（2D-NMR）进行了全面表征。对分离出的化合物的二苯基苦味酰基自由基清除活性进行了评估，结果表明山柰酚--吡喃葡萄糖基-（1→3） --吡喃葡萄糖苷（）和芦丁（）具有潜在的抗氧化活性，其半数抑制浓度（IC）值分别为139μg/mL和22.5μg/mL。
