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在连续流动微反应器中，由脂肪酶TL IM催化串联合成含糖类香豆素衍生物的可持续创新方法。

A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from in continuous-flow microreactors.

作者信息

Du Li-Hua, Chen Ping-Feng, Long Rui-Jie, Xue Miao, Luo Xi-Ping

机构信息

College of Pharmaceutical Science, ZheJiang University of Technology Hangzhou 310014 China

Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, Zhejiang A&F University Hangzhou 311300 China.

出版信息

RSC Adv. 2020 Apr 2;10(22):13252-13259. doi: 10.1039/d0ra00879f. eCollection 2020 Mar 30.

DOI:10.1039/d0ra00879f
PMID:35492096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9051562/
Abstract

We developed an efficient and environmentally friendly two-step tandem methodology for the synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from in continuous-flow microreactors. Compared to those observed for other methods, the salient features of this work including green reaction conditions, short residence time (50 min), and catalysts are more readily available and the biocatalysis reaction process is efficient and easy to control. This two-step tandem synthesis of coumarin derivatives using the continuous-flow technology is a proof of concept that opens the use of enzymatic microreactors in coumarin derivative biotransformations.

摘要

我们开发了一种高效且环保的两步串联方法，用于在连续流动微反应器中由脂肪酶TL IM催化合成含糖类香豆素衍生物。与其他方法相比，这项工作的显著特点包括绿色反应条件、短停留时间（50分钟）、催化剂更容易获得，以及生物催化反应过程高效且易于控制。使用连续流动技术进行香豆素衍生物的两步串联合成是一个概念验证，开启了酶促微反应器在香豆素衍生物生物转化中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ddd/9051562/60d5a9a17c97/d0ra00879f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ddd/9051562/54bc48b5f539/d0ra00879f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ddd/9051562/67c0bca2af7f/d0ra00879f-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ddd/9051562/a37e2bd1e1b6/d0ra00879f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ddd/9051562/60d5a9a17c97/d0ra00879f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ddd/9051562/54bc48b5f539/d0ra00879f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ddd/9051562/67c0bca2af7f/d0ra00879f-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ddd/9051562/a37e2bd1e1b6/d0ra00879f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ddd/9051562/60d5a9a17c97/d0ra00879f-f7.jpg

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