Ezeome Emmanuel R, Yawe King-David T, Ayandipo Omobolaji, Badejo Olawale, Adebamowo Sally N, Achusi Benerdin, Fowotade Adeola, Ogun Gabriel, Adebamowo Clement A
Department of Surgery, College of Medicine, University of Nigeria, Enugu, Nigeria.
Oncology Center, University of Nigeria Teaching Hospital, Enugu, Nigeria.
Front Oncol. 2022 Apr 13;12:856182. doi: 10.3389/fonc.2022.856182. eCollection 2022.
Breast cancer is now the commonest cancer in most sub-Saharan African countries. Few studies of the epidemiology and genomics of breast cancer and its molecular subtypes in these countries have been done. The African Female Breast Cancer Epidemiology (AFBRECANE) study, a part of the Human Heredity and Health in Africa (H3Africa) initiative, is designed to study the genomics and epidemiology of breast cancer and its molecular subtypes in Nigerian women. We link recruitment of breast cancer cases at study sites with population-based cancer registries activities to enable ascertainment of the incidence of breast cancer and its molecular subtypes. We use centralized laboratory processing to characterize the histopathological and molecular diagnosis of breast cancer and its subtypes using multiple technologies. By combining genome-wide association study (GWAS) data from this study with that generated from 12,000 women participating in our prospective cohort study of cervical cancer, we conduct GWAS of breast cancer in an entirely indigenous African population. We test associations between dietary intakes and breast cancer and focus on vitamin D which we measure using dietary intakes, serum vitamin D, and Mendelian randomization. This paper describes the AFBRECANE project, its design, objectives and anticipated contributions to knowledge and understanding of breast cancer.
乳腺癌目前是撒哈拉以南非洲大多数国家最常见的癌症。这些国家中针对乳腺癌及其分子亚型的流行病学和基因组学的研究很少。非洲女性乳腺癌流行病学（AFBRECANE）研究是非洲人类遗传与健康（H3Africa）倡议的一部分，旨在研究尼日利亚女性乳腺癌及其分子亚型的基因组学和流行病学。我们将研究地点的乳腺癌病例招募与基于人群的癌症登记活动联系起来，以确定乳腺癌及其分子亚型的发病率。我们使用集中式实验室处理，通过多种技术对乳腺癌及其亚型进行组织病理学和分子诊断。通过将本研究的全基因组关联研究（GWAS）数据与参与我们宫颈癌前瞻性队列研究的12000名女性的数据相结合，我们在完全本土的非洲人群中进行乳腺癌的GWAS。我们测试饮食摄入量与乳腺癌之间的关联，并重点关注我们通过饮食摄入量、血清维生素D和孟德尔随机化来测量的维生素D。本文描述了AFBRECANE项目、其设计、目标以及对乳腺癌知识和理解的预期贡献。
