Rouh Hossein, Tang Yao, Zhang Sai, Ali Ahmed I M, Surowiec Kazimierz, Unruh Daniel, Li Guigen
Department of Chemistry and Biochemistry, Texas Tech University Lubbock Texas 79409-1061 USA
RSC Adv. 2021 Dec 14;11(63):39790-39796. doi: 10.1039/d1ra08323f. eCollection 2021 Dec 13.
In this work, we present a strategy for the preparation of functionalized 4-chromene derivatives a CsCO-catalyzed [4 + 2] cycloaddition of enantiopure chiral salicyl -phosphonyl imines with allenoates. Fifteen examples were achieved in excellent yields and diastereoselectivity. The products were purified simply by washing the crude mixture with hexanes following the Group-Assisted Purification (GAP) chemistry/technology to bypass traditional separation methods. The absolute configuration was unambiguously determined by X-ray structure analysis.
在本工作中，我们展示了一种制备官能化4-色烯衍生物的策略——通过碳酸铯催化对映体纯的手性水杨醛-膦酰亚胺与联烯酸酯进行[4+2]环加成反应。以优异的产率和非对映选择性得到了15个实例。按照基团辅助纯化（GAP）化学/技术，通过用己烷洗涤粗混合物，简单地对产物进行了纯化，从而避开了传统的分离方法。通过X射线结构分析明确确定了绝对构型。
