Pazo J H, Jerusalinsky D, Medina J H, Tumilasci O R, Levi de Stein M, Rascosky S
Gen Pharmacol. 1987;18(1):83-5. doi: 10.1016/0306-3623(87)90174-1.
Administration of haloperidol influences peripheral non-dopaminergic receptors. The sialagogue response of the submandibular glands of the rats to methacholine was enhanced by chronic administration of haloperidol. The binding of [3H]QNB to muscarinic receptors in the submandibular glands was not changed by chronic haloperidol. The supersensitivity of postsynaptic cholinergic receptors to drugs in haloperidol treated rats is not related to changes in the number or affinity of such receptors. This paper confirmed the sialagogue supersensitivity to adrenergic drugs related to an increase in alpha 1-adrenoceptors in the submandibular glands of haloperidol injected rats.
给予氟哌啶醇会影响外周非多巴胺能受体。长期给予氟哌啶醇可增强大鼠下颌下腺对乙酰甲胆碱的唾液分泌反应。长期给予氟哌啶醇不会改变[3H]QNB与下颌下腺毒蕈碱受体的结合。在氟哌啶醇处理的大鼠中，突触后胆碱能受体对药物的超敏反应与这些受体的数量或亲和力变化无关。本文证实了氟哌啶醇注射大鼠下颌下腺中与α1-肾上腺素能受体增加相关的对肾上腺素能药物的唾液分泌超敏反应。
