Barr G D, Hudson M J, Priddle J D, Jewell D P
Gut. 1987 Feb;28(2):186-9. doi: 10.1136/gut.28.2.186.
The colonic faecal and mucosal associated bacterial populations of five patients with ulcerative colitis and four control patients were studied in detail to assess their ability to produce IgA1-proteases. A total of 330 bacterial strains were isolated from the patients with ulcerative colitis and IgA1-protease activity was unable to be reliably shown in any. It is therefore unlikely that such enzyme production by colonic bacteria plays a significant role in the pathogenesis of ulcerative colitis.
对5例溃疡性结肠炎患者和4例对照患者的结肠粪便及黏膜相关细菌群体进行了详细研究，以评估它们产生IgA1蛋白酶的能力。从溃疡性结肠炎患者中总共分离出330株细菌菌株，但未在任何菌株中可靠地检测到IgA1蛋白酶活性。因此，结肠细菌产生这种酶在溃疡性结肠炎发病机制中不太可能起重要作用。
