溃疡性结肠炎患者结肠细菌蛋白酶对IgA1和分泌型IgA的作用
Colonic bacterial proteases to IgA1 and sIgA in patients with ulcerative colitis.
作者信息
Barr G D, Hudson M J, Priddle J D, Jewell D P
出版信息
Gut. 1987 Feb;28(2):186-9. doi: 10.1136/gut.28.2.186.
Abstract
The colonic faecal and mucosal associated bacterial populations of five patients with ulcerative colitis and four control patients were studied in detail to assess their ability to produce IgA1-proteases. A total of 330 bacterial strains were isolated from the patients with ulcerative colitis and IgA1-protease activity was unable to be reliably shown in any. It is therefore unlikely that such enzyme production by colonic bacteria plays a significant role in the pathogenesis of ulcerative colitis.
摘要
对5例溃疡性结肠炎患者和4例对照患者的结肠粪便及黏膜相关细菌群体进行了详细研究，以评估它们产生IgA1蛋白酶的能力。从溃疡性结肠炎患者中总共分离出330株细菌菌株，但未在任何菌株中可靠地检测到IgA1蛋白酶活性。因此，结肠细菌产生这种酶在溃疡性结肠炎发病机制中不太可能起重要作用。
相似文献
1
Colonic bacterial proteases to IgA1 and sIgA in patients with ulcerative colitis.溃疡性结肠炎患者结肠细菌蛋白酶对IgA1和分泌型IgA的作用
Gut. 1987 Feb;28(2):186-9. doi: 10.1136/gut.28.2.186.
2
The IgA1 proteases of pathogenic bacteria.致病细菌的IgA1蛋白酶。
Annu Rev Microbiol. 1983;37:603-22. doi: 10.1146/annurev.mi.37.100183.003131.
3
Clostridium ramosum, an IgA protease-producing species and its ecology in the human intestinal tract.多枝梭菌，一种产生IgA蛋白酶的菌种及其在人类肠道中的生态。
Microbiol Immunol. 1985;29(11):1019-28. doi: 10.1111/j.1348-0421.1985.tb00892.x.
4
Lack of cleavage of immunoglobulin A (IgA) from rhesus monkeys by bacterial IgA1 proteases.细菌IgA1蛋白酶对恒河猴免疫球蛋白A（IgA）的切割缺失。
Infect Immun. 1991 Jun;59(6):2219-21. doi: 10.1128/iai.59.6.2219-2221.1991.
5
Resistance of normal serum IgA and secretory IgA to bacterial IgA proteases: evidence for the presence of enzyme-neutralizing antibodies in both serum and secretory IgA, and also in serum IgG.正常血清IgA和分泌型IgA对细菌IgA蛋白酶的抗性：血清和分泌型IgA以及血清IgG中存在酶中和抗体的证据。
Microbiol Immunol. 1987;31(11):1097-106. doi: 10.1111/j.1348-0421.1987.tb01341.x.
6
Actions of three clostridial IgA proteases on distinct forms of immunoglobulin A molecules.三种梭菌IgA蛋白酶对不同形式免疫球蛋白A分子的作用。
Immunology. 1991 Jun;73(2):235-8.
7
IgA protease-producing bacteria in patients with ulcerative colitis.溃疡性结肠炎患者中产生IgA蛋白酶的细菌。
Gut. 1987 Jul;28(7):917. doi: 10.1136/gut.28.7.917.
8
Perturbation of mucosal immune defence mechanisms by bacterial IgA proteases.细菌IgA蛋白酶对黏膜免疫防御机制的干扰。
Bull Eur Physiopathol Respir. 1983 Mar-Apr;19(2):99-104.
9
Cleavage of chimpanzee secretory immunoglobulin A by Haemophilus influenzae IgA1 protease.流感嗜血杆菌IgA1蛋白酶对黑猩猩分泌型免疫球蛋白A的切割作用。
Microb Pathog. 1991 Jul;11(1):39-46. doi: 10.1016/0882-4010(91)90092-o.
10
Bacterial invasion into the colonic mucosa in ulcerative colitis.溃疡性结肠炎中细菌对结肠黏膜的侵袭。
J Gastroenterol Hepatol. 1993 Jan-Feb;8(1):116-8. doi: 10.1111/j.1440-1746.1993.tb01184.x.
本文引用的文献
1
Ecology and nature of immunoglobulin A1 protease-producing streptococci in the human oral cavity and pharynx.人类口腔和咽部产生免疫球蛋白A1蛋白酶的链球菌的生态学与特性
Infect Immun. 1981 Mar;31(3):868-73. doi: 10.1128/iai.31.3.868-873.1981.
2
3
The IgA1 proteases of pathogenic bacteria.致病细菌的IgA1蛋白酶。
Annu Rev Microbiol. 1983;37:603-22. doi: 10.1146/annurev.mi.37.100183.003131.
4
The microbial flora of the rectal mucosa and faeces of patients with Crohn's disease before and during antimicrobial chemotherapy.克罗恩病患者在抗菌化疗前及化疗期间直肠黏膜和粪便的微生物菌群。
J Med Microbiol. 1984 Dec;18(3):335-45. doi: 10.1099/00222615-18-3-335.
5
Medium without rumen fluid for nonselective enumeration and isolation of rumen bacteria.用于瘤胃细菌非选择性计数和分离的不含瘤胃液的培养基。
Appl Microbiol. 1966 Sep;14(5):794-801. doi: 10.1128/am.14.5.794-801.1966.
6
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
7
A quantitative comparison of the faecal flora of patients with ulcerative colitis and that of normal persons.溃疡性结肠炎患者与正常人粪便菌群的定量比较。
J Pathol Bacteriol. 1967 Oct;94(2):439-44. doi: 10.1002/path.1700940225.
8
Transport and storage of faeces for bacteriological examination.用于细菌学检查的粪便运输与储存。
J Appl Bacteriol. 1971 Jun;34(2):477-83. doi: 10.1111/j.1365-2672.1971.tb02307.x.
9
Properties of strains of Escherichia coli isolated from the faeces of patients with ulcerative colitis, patients with acute diarrhoea and normal persons.从溃疡性结肠炎患者、急性腹泻患者及正常人粪便中分离出的大肠杆菌菌株的特性。
J Pathol Bacteriol. 1968 Jan;95(1):101-13. doi: 10.1002/path.1700950112.
Zotero 插件