Williams B M, Sanders J E, Clift R A, Hickman R O, Bensinger W I, Buckner C D, Thomas E D
J Clin Apher. 1987;3(3):171-3. doi: 10.1002/jca.2920030309.
Between June 1982 and April 1984, 67 adult granulocyte donors were randomized to receive external arteriovenous shunts or modified right atrial catheters as vascular access for daily granulocyte collections using blood cell separators. Six of 32 donors with shunts and 2 of 35 donors with right atrial catheters experienced failure of the access method. Local infection occurred in one donor with a shunt and one donor with a right atrial catheter. Bacteremia occurred in one donor with a right atrial catheter. Specified whole blood flow rates of 50-65 ml/minute were achieved with 28 of 32 shunts and 29 of 35 right atrial catheters (P = NS). The majority of the donors in each group tolerated the vascular access without significant problems. This study demonstrates that modified right atrial catheters can be successfully used as method of vascular access for single donor granulocyte collection with blood cell separators.
在1982年6月至1984年4月期间，67名成年粒细胞供者被随机分配接受动静脉外分流术或改良右心房导管，作为使用血细胞分离器每日采集粒细胞的血管通路。32名接受分流术的供者中有6名，35名接受右心房导管的供者中有2名出现血管通路方法失败。1名接受分流术的供者和1名接受右心房导管的供者发生局部感染。1名接受右心房导管的供者发生菌血症。32个分流术中的28个以及35个右心房导管中的29个达到了50 - 65毫升/分钟的特定全血流速（P = 无显著性差异）。每组中的大多数供者耐受血管通路，没有明显问题。本研究表明，改良右心房导管可成功用作使用血细胞分离器从单个供者采集粒细胞的血管通路方法。
