反应扩散模型作为理解核黄素在“眼部防御”制剂中作用的框架。

Reaction-diffusion model as framework for understanding the role of riboflavin in "eye defence" formulations.

作者信息

Di Nezza Francesca, Caruso Ciro, Costagliola Ciro, Ambrosone Luigi

机构信息

Consorzio per Lo Sviluppo Dei Sistemi a Grande Interfase (C.S.G.I.), c/o Department of Medicine and Health Sciences V. Tiberio, University of Molise 86100 Campobasso Italy

Corneal Transplant Center, Pellegrini Hospital Naples Italy.

出版信息

RSC Adv. 2020 Apr 16;10(25):14965-14971. doi: 10.1039/d0ra00417k. eCollection 2020 Apr 8.

DOI:10.1039/d0ra00417k

PMID:35497118

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9052030/

Abstract

Analysis of UV-visible spectra, performed on commercial riboflavin-based eye drops, showed that absorbance is a saturating function of vitamin concentration. This implies a threshold concentration, , such that for riboflavin concentration > the absorbance remains constant and the effectiveness of the eye drops is independent of the dose used. These experimental results were combined with a diffusion-reaction model to elucidate the mechanism of action within the cornea. The model predicts that the eye drops have a low effectiveness on UVB and UVC, while they have a good performance for UVA. Indeed, at the center of the cornea the transmittance is significantly reduced and after 1 h it is reduced by about 70% compared to a cornea devoid of eye drops.

摘要

对市售核黄素滴眼液进行的紫外可见光谱分析表明，吸光度是维生素浓度的饱和函数。这意味着存在一个阈值浓度，使得当核黄素浓度大于该阈值时，吸光度保持恒定，滴眼液的有效性与所用剂量无关。这些实验结果与扩散反应模型相结合，以阐明角膜内的作用机制。该模型预测，滴眼液对UVB和UVC的有效性较低，而对UVA的性能良好。实际上，在角膜中心，透光率显著降低，与未使用滴眼液的角膜相比，1小时后透光率降低约70%。