Wang Pei, Tong Fei, Luo Jun, Li Zhihua, Wei Junchao, Liu Yuangang
School of Stomatology, Nanchang University, Nanchang, China.
Jiangxi Province Key Laboratory of Oral Biomedicine, Nanchang, China.
Front Bioeng Biotechnol. 2022 Apr 13;10:845821. doi: 10.3389/fbioe.2022.845821. eCollection 2022.
The shape of nanoparticles can determine their physical properties and then greatly impact the physiological reactions on cells or tissues during treatment. Traditionally spherical nanoparticles are more widely applied in biomedicine but are not necessarily the best. The superiority of anisotropic nanoparticles has been realized in recent years. The synthesis of the distinct-shaped metal/metal oxide nanoparticles is easily controlled. However, their biotoxicity is still up for debate. Hence, we designed CaCO nanorods for drug delivery prepared at mild condition by polysaccharide-regulated biomineralization in the presence of fucoidan with sulfate groups. The CaCO nanorods with a pH sensitivity-loaded antitumor drug mitoxantrone hydrochloride (MTO) showed excellent antitumor efficacy for the HeLa cells and MCF-7 cells . We believe that anisotropic nanoparticles will bring forth an emblematic shift in nanotechnology for application in biomedicine.
纳米颗粒的形状可以决定其物理性质，进而在治疗过程中对细胞或组织的生理反应产生重大影响。传统上，球形纳米颗粒在生物医学中应用更为广泛，但不一定是最佳选择。近年来，各向异性纳米颗粒的优势已得到认可。独特形状的金属/金属氧化物纳米颗粒的合成易于控制。然而，它们的生物毒性仍存在争议。因此，我们设计了通过在含有硫酸基团的岩藻依聚糖存在下进行多糖调节生物矿化在温和条件下制备的用于药物递送的碳酸钙纳米棒。负载有pH敏感性抗肿瘤药物盐酸米托蒽醌（MTO）的碳酸钙纳米棒对HeLa细胞和MCF-7细胞显示出优异的抗肿瘤疗效。我们相信，各向异性纳米颗粒将在生物医学应用的纳米技术中带来具有标志性的转变。
