Fujian Provincial Key Laboratory of Biochemical Technology, Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, P. R. China.
Jiangxi Key Laboratory of Stomatology and Biomedicine, School of Stomatology, Nanchang University, Nanchang 330006, P. R. China.
ACS Appl Mater Interfaces. 2021 Aug 11;13(31):37563-37577. doi: 10.1021/acsami.1c11138. Epub 2021 Aug 2.
Despite its success against cancer, photothermal therapy (PTT) (>50 °C) suffers from several limitations such as triggering inflammation and facilitating immune escape and metastasis and also damage to the surrounding normal cells. Mild-temperature PTT has been proposed to override these shortcomings. We developed a nanosystem using HepG2 cancer cell membrane-cloaked zinc glutamate-modified Prussian blue nanoparticles with triphenylphosphine-conjugated lonidamine (HmPGTL NPs). This innovative approach achieved an efficient mild-temperature PTT effect by downregulating the production of intracellular ATP. This disrupts a section of heat shock proteins that cushion cancer cells against heat. The physicochemical properties, anti-tumor efficacy, and mechanisms of HmPGTL NPs both and were investigated. Moreover, the nanoparticles cloaked with the HepG2 cell membrane substantially prolonged the circulation time . Overall, the designed nanocomposites enhance the efficacy of mild-temperature PTT by disrupting the production of ATP in cancer cells. Thus, we anticipate that the mild-temperature PTT nanosystem will certainly present its enormous potential in various biomedical applications.
尽管光热疗法（PTT）在对抗癌症方面取得了成功（>50°C），但它仍存在一些局限性，如引发炎症、促进免疫逃逸和转移，以及对周围正常细胞的损伤。因此，人们提出了温和温度 PTT 来克服这些缺点。我们开发了一种纳米系统，该系统使用 HepG2 癌细胞膜包裹的锌谷氨酸修饰的普鲁士蓝纳米颗粒与三苯基膦偶联的 lonidamine（HmPGTL NPs）。这种创新方法通过下调细胞内 ATP 的产生，实现了高效的温和温度 PTT 效应。这破坏了一段热休克蛋白，使癌细胞免受热量的影响。我们研究了 HmPGTL NPs 的理化性质、抗肿瘤功效和机制。此外，HepG2 细胞膜包裹的纳米颗粒大大延长了循环时间。总的来说，设计的纳米复合材料通过破坏癌细胞中 ATP 的产生来提高温和温度 PTT 的疗效。因此，我们预计温和温度 PTT 纳米系统将在各种生物医学应用中展现出巨大的潜力。
