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通过动态静电排斥反相（d-ERRP）液相色谱法增强碱性肽的分离

Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography.

作者信息

Mazzoccanti Giulia, Manetto Simone, Bassan Michele, Foschini Alberto, Orlandin Andrea, Ricci Antonio, Cabri Walter, Ismail Omar H, Catani Martina, Cavazzini Alberto, Gasparrini Francesco

机构信息

Department of Pharmaceutical Chemistry and Technology, "Sapienza" University of Rome Rome Italy

Fresenius Kabi iPSUM Piazza Maestri del Lavoro 7, Cernusco sul Naviglio 20063 MI Italy

出版信息

RSC Adv. 2020 Mar 27;10(21):12604-12610. doi: 10.1039/d0ra01296c. eCollection 2020 Mar 24.

DOI:10.1039/d0ra01296c
PMID:35497586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9051050/
Abstract

The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market.

摘要

一种新型色谱方法应用于结构中带有碱性氨基酸的治疗性肽，能够以前所未有的方式分离其相关杂质（包括差向异构的等压杂质），从而产生了一种用于评估市场上这些药物质量的卓越分析工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e86f/9051050/9c4aeb11d93a/d0ra01296c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e86f/9051050/5a1578a9cf46/d0ra01296c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e86f/9051050/f1178b8bb4b6/d0ra01296c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e86f/9051050/e394b48b2b49/d0ra01296c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e86f/9051050/9c4aeb11d93a/d0ra01296c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e86f/9051050/5a1578a9cf46/d0ra01296c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e86f/9051050/f1178b8bb4b6/d0ra01296c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e86f/9051050/e394b48b2b49/d0ra01296c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e86f/9051050/9c4aeb11d93a/d0ra01296c-f4.jpg

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