Eriksson Johan G, Salonen Minna K, von Bonsdorff Mikaela B, Wasenius Niko, Kajantie Eero, Kautiainen Hannu, Mikkola Tuija M
Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Folkhälsan Research Center, Helsinki, Finland.
Front Cardiovasc Med. 2022 Apr 14;9:865544. doi: 10.3389/fcvm.2022.865544. eCollection 2022.
The main objective of this study was to study predictors of vascular health with focus on adiposity-related factors. Glucose metabolism, blood lipids, inflammatory markers and body composition were assessed 15 years before assessment of vascular health which was assessed with pulse wave velocity (PWV) in 660 subjects born 1934-44. In a univariate analysis in women the strongest association with PWV was seen for age, systolic blood pressure, dysglycemia, dyslipidemia, inflammatory markers and body fat percentage measured in late midlife and PWV measured 15 years later. In men age, body mass index (BMI), systolic blood pressure, dysglycemia, and body fat percentage in late midlife were associated with PWV. One novel finding was that adiposity-related factors were strong predictors of vascular health, something not fully encapsulated in BMI, lean body mass or body fat percentage alone. A higher fat mass index was associated with worse vascular health, which was not ameliorated by a higher lean mass index. Our findings stress the importance to study body composition and fat and lean body mass simultaneously because of their close interaction with each other also in relation to vascular health.
本研究的主要目的是研究血管健康的预测因素，重点关注与肥胖相关的因素。在对660名出生于1934年至1944年的受试者进行血管健康评估前15年，对其葡萄糖代谢、血脂、炎症标志物和身体成分进行了评估。血管健康评估采用脉搏波速度（PWV）。在女性的单变量分析中，与PWV关联最强的因素为年龄、收缩压、血糖异常、血脂异常、炎症标志物以及中年后期测量的体脂百分比和15年后测量的PWV。在男性中，年龄、体重指数（BMI）、收缩压、血糖异常以及中年后期的体脂百分比与PWV相关。一个新发现是，与肥胖相关的因素是血管健康的强有力预测因素，这一点无法仅通过BMI、瘦体重或体脂百分比完全体现。较高的脂肪质量指数与较差的血管健康相关，较高的瘦体重指数并不能改善这种情况。我们的研究结果强调了同时研究身体成分以及脂肪和瘦体重的重要性，因为它们在血管健康方面也相互密切作用。
