Reiß Melanie, Brietzke Andreas, Eickner Thomas, Stein Florian, Villinger Alexander, Vogel Christian, Kragl Udo, Jopp Stefan
Institute of Chemistry, University of Rostock Albert-Einstein-Straße 3a 18059 Rostock Germany
Institute of Biomedical Engineering, University of Rostock Friedrich-Barnewitz-Straße 4 18119 Rostock Germany.
RSC Adv. 2020 Apr 7;10(24):14299-14304. doi: 10.1039/d0ra01370f. eCollection 2020 Apr 6.
The large pool of naturally occurring carbohydrates with their diversity in chirality and structure led to the idea of a systematic investigation of carbohydrate based ILs. To this end, we investigated the influence of different ether groups, mainly methyl or ethyl ether, on the secondary OH groups as well as different configurations on physical properties such as melting point, thermostability and especially the influence on cell toxicity. For this investigation we chose α- and β-methyl-, β-allyl- and β-phenyl d-glucopyranose as well as four 1-deoxy-pentoses. In order to be able to classify the results, more ionic liquids with different structural motives were examined for cytotoxicity. Here, we present data that confirm the biocompatibility of such ILs consisting of naturally occurring molecules or their derivatives. The synthesized carbohydrate based ILs were tested for their suitability as additives in coatings for medical applications such as drug-eluting balloons.
大量天然存在的碳水化合物在手性和结构上具有多样性，这引发了对基于碳水化合物的离子液体进行系统研究的想法。为此，我们研究了不同醚基（主要是甲基或乙基醚）对仲羟基的影响，以及不同构型对诸如熔点、热稳定性等物理性质的影响，特别是对细胞毒性的影响。为了进行这项研究，我们选择了α-和β-甲基、β-烯丙基和β-苯基-D-吡喃葡萄糖以及四种1-脱氧戊糖。为了能够对结果进行分类，我们还研究了更多具有不同结构 motif 的离子液体的细胞毒性。在此，我们展示的数据证实了此类由天然存在的分子或其衍生物组成的离子液体的生物相容性。所合成的基于碳水化合物的离子液体被测试其作为医疗应用涂层（如药物洗脱球囊）添加剂的适用性。
