急性洋地黄中毒：静脉注射硫酸镁的作用

Acute digitalis poisoning: the role of intravenous magnesium sulfate.

作者信息

Reisdorff E J, Clark M R, Walters B L

出版信息

J Emerg Med. 1986;4(6):463-9. doi: 10.1016/0736-4679(86)90176-9.

Abstract

Acute digitalis poisoning is a complex emergency with a reported mortality rate of 3% to 25%. In severe overdose, the sodium, potassium-adenosine triphosphatase system is severely inhibited, leading to cardiac dysrhythmias and an elevation of the serum potassium. Magnesium, a cofactor regulating this ion transport system, can successfully treat acute digitalis-induced rhythm disturbances and restore the transmembrane potassium gradient. This paper discusses the cellular mechanism involved in digitalis toxicity and reviews the literature concerning the use of magnesium in acute cardiac glycoside poisoning.

摘要

急性洋地黄中毒是一种复杂的急症，据报道死亡率为3%至25%。在严重过量的情况下，钠钾-三磷酸腺苷酶系统受到严重抑制，导致心律失常和血清钾升高。镁作为调节该离子转运系统的辅助因子，可成功治疗急性洋地黄引起的节律紊乱并恢复跨膜钾梯度。本文讨论了洋地黄毒性所涉及的细胞机制，并综述了有关镁在急性强心苷中毒中应用的文献。