Beissbarth Jemima, Smith-Vaughan Heidi C, Cheng Allen C, Morris Peter S, Leach Amanda J
Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Front Pediatr. 2022 Apr 14;10:804373. doi: 10.3389/fped.2022.804373. eCollection 2022.
Otitis media (OM) is a common childhood illness, often resolving without intervention and acute and long-term complications are rare. However, Australian Aboriginal and Torres Strait Islander infants and children experience a high burden of OM and are at high risk of complications (tympanic membrane perforation and chronic infections). Bacterial OM is commonly associated with , non-typeable , and . BIGDATA is a data asset combining over 25 years of microbiology and OM surveillance research from the Ear Health Research Program at Menzies School of Health Research (Northern Territory, Australia), including 11 randomized controlled trials, four cohort studies, eight surveys in over 30 remote communities (including data from Western Australia), and five surveys of urban childcare centers including Aboriginal and Torres Strait Islander and non-Indigenous children. Outcome measures include clinical examinations (focusing on OM), antibiotic prescriptions, pneumococcal vaccination, modifiable risk factors such as smoking and household crowding, and nasopharyngeal and ear discharge microbiology including antimicrobial resistance testing.
The initial series of projects are planned to address the following key knowledge gaps: (i) otitis media prevalence and severity over pre pneumococcal conjugate vaccines (PCVs) and three eras of increasing PCV valency; (ii) impact of increasing valency PCVs on nasopharyngeal carriage dynamics of pneumococcal serotypes, and antimicrobial resistance; (iii) impact of increasing valency PCVs on nasopharyngeal carriage dynamics and antimicrobial resistance of other otopathogens; and (iv) serotype specific differences between children with acute OM and OM with effusion or without OM. These data will be utilized to identify research gaps, providing evidence-based prioritization for ongoing research.
Data asset creation and priority analyses were approved by the Human Research Ethics Committee of Northern Territory Department of Health and Menzies School of Health Research (EC00153, 18-3281), the Child and Adolescent Health Service Human Research Ethics Committee and Western Australian Aboriginal Health Ethics Committee. Dissemination will be through peer review publication and conference presentations.
中耳炎（OM）是一种常见的儿童疾病，通常无需干预即可痊愈，急性和长期并发症很少见。然而，澳大利亚原住民和托雷斯海峡岛民的婴幼儿中耳炎负担较重，且有较高的并发症风险（鼓膜穿孔和慢性感染）。细菌性中耳炎通常与、不可分型以及有关。BIGDATA是一项数据资产，结合了来自澳大利亚北部地区梅齐斯健康研究学院耳部健康研究项目25多年的微生物学和中耳炎监测研究，包括11项随机对照试验、4项队列研究、对30多个偏远社区的8项调查（包括来自西澳大利亚的数据）以及对城市儿童保育中心的5项调查，其中包括原住民和托雷斯海峡岛民儿童以及非原住民儿童。结果指标包括临床检查（重点是中耳炎）、抗生素处方、肺炎球菌疫苗接种、可改变的风险因素如吸烟和家庭拥挤情况，以及鼻咽部和耳部分泌物微生物学，包括抗菌药物耐药性检测。
最初的一系列项目计划解决以下关键知识空白：（i）在肺炎球菌结合疫苗（PCV）接种前以及PCV价数不断增加的三个时期的中耳炎患病率和严重程度；（ii）PCV价数增加对肺炎球菌血清型鼻咽部携带动态以及抗菌药物耐药性的影响；（iii）PCV价数增加对其他耳病原体鼻咽部携带动态和抗菌药物耐药性的影响；以及（iv）急性中耳炎患儿与积液性中耳炎或无中耳炎患儿之间的血清型特异性差异。这些数据将用于识别研究空白，为正在进行的研究提供基于证据的优先级排序。
数据资产创建和优先级分析已获得北领地卫生部人类研究伦理委员会和梅齐斯健康研究学院（EC00153，18 - 3281）、儿童和青少年健康服务人类研究伦理委员会以及西澳大利亚原住民健康伦理委员会的批准。传播将通过同行评审发表和会议报告进行。
