Lack of Association Between Polymorphisms and Colorectal Cancer Risk: A Case-Control Study.

Functional variants of immune-related genes may be implicated in the occurrence of colorectal cancer (CRC). In this study, () (rs10204525 T/C), (rs7421861 A/G), and (rs2227982 A/G) loci were selected to explore gene expression and the potential susceptibility to the development of CRC. Here, 1,003 CRC patients and 1,303 controls were included and three tagging loci were selected and analyzed by using SNPscan genotyping assays. SHESIS software was harnessed to obtain the haplotypes of the gene. We found that the genotype and allele distribution of tagging loci did not significantly affect the risk of CRC. Adjustment for body mass index, age, smoking, alcohol using and sex also found that tagging loci did not influence the occurrence of CRC. In conclusion, this study suggests that the tagging loci (rs10204525, rs7421861, and rs2227982) are not correlated with CRC susceptibility.