脑血影蛋白（240/235）和脑血影蛋白（240/235E）：小鼠脑发育过程中的差异表达
Brain spectrin(240/235) and brain spectrin(240/235E): differential expression during mouse brain development.
作者信息
Riederer B M, Zagon I S, Goodman S R
出版信息
J Neurosci. 1987 Mar;7(3):864-74. doi: 10.1523/JNEUROSCI.07-03-00864.1987.
Mouse brain contains at least 2 distinct spectrin subtypes: brain spectrin(240/235) and brain spectrin(240/235E) (Riederer et al., 1986). In this study, we demonstrate that these subtypes are differentially expressed during mouse brain development. Brain spectrin(240/235) can be detected in fetal tissue and increases 2-fold during brain development. This subtype is enriched in the cortical cytoplasm of germinative neural cells and is also found in fibers resembling axons as early as fetal life. Brain spectrin(240/235E), which is specifically detected with antibodies to red blood cell spectrin, is below the limits of detection in fetal and neonatal brain but rapidly increases in concentration during the second postnatal week. Brain spectrin(240/235E) is confined to the cell body and dendrites of differentiating neurons and to glial cells but is not expressed in mitotic cells. This subtype is most prominent in granule cells of the cerebellum and dentate gyrus in the hippocampus.
小鼠大脑至少包含两种不同的血影蛋白亚型
脑血影蛋白（240/235）和脑血影蛋白（240/235E）（里德雷尔等人，1986年）。在本研究中，我们证明这些亚型在小鼠大脑发育过程中差异表达。脑血影蛋白（240/235）可在胎儿组织中检测到，在大脑发育过程中增加两倍。这种亚型在生发神经细胞的皮质细胞质中富集，早在胎儿期就可在类似轴突的纤维中发现。脑血影蛋白（240/235E），可通过抗红细胞血影蛋白抗体特异性检测到，在胎儿和新生儿大脑中低于检测限，但在出生后第二周浓度迅速增加。脑血影蛋白（240/235E）局限于分化神经元的细胞体和树突以及胶质细胞，但在有丝分裂细胞中不表达。这种亚型在小脑颗粒细胞和海马齿状回中最为突出。
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