Department of Mechanical Engineering, Villanova University, PA, 19085, USA; Cellular Biomechanics and Sport Science Laboratory, Villanova University, PA, 19085, USA.
Department of Mechanical Engineering, Villanova University, PA, 19085, USA.
J Mech Behav Biomed Mater. 2022 Jul;131:105255. doi: 10.1016/j.jmbbm.2022.105255. Epub 2022 Apr 27.
In this study, mechanotransduction is investigated through a physics-based viscoelastic model describing the arterial diameter response during a brachial artery flow mediated dilation (BAFMD) test. The study is a significant extension of two earlier studies by the same group, where only the elastic response was considered. Experimental BAFMD responses were collected from 12 healthy volunteers. The arterial wall's elastic and viscous properties were treated as local variable quantities depending on the wall shear stress (WSS) sensed by mechanotransduction. The dimensionless parameters, arising from the model which serve as a quantitative assessment of the artery's physical state, were adjusted to replicate the experimental response. Among those dimensionless parameters, the viscoelastic ratio, which reflects the relative strength of the viscous response compared to its elastic counterpart, is of special relevance to this paper's main conclusion. Based on the results, it is concluded that the arterial wall's mechanical behavior is predominantly elastic, at least in the strict context of the BAFMD test. Recommendations for potential future research and applications are provided.
在这项研究中，通过一个基于物理的黏弹性模型来研究机械转导，该模型描述了在肱动脉血流介导扩张（BAFMD）试验期间动脉直径的响应。该研究是同一组之前两项研究的重要扩展，其中仅考虑了弹性响应。从 12 名健康志愿者中收集了动脉的弹性和粘性特性作为局部变量，这些变量取决于机械转导感知到的壁切应力（WSS）。从模型中得出的无量纲参数可作为动脉物理状态的定量评估，并进行调整以复制实验响应。在这些无量纲参数中，黏弹性比特别重要，因为它反映了与弹性响应相比粘性响应的相对强度，这是本文主要结论的关键。基于这些结果，可以得出结论，至少在严格的 BAFMD 试验背景下，动脉壁的力学行为主要是弹性的。还提供了对未来潜在研究和应用的建议。
