金刚烷胺在减少多发性硬化症复发方面的有效性。
Effectiveness of amantadine in reducing relapses in multiple sclerosis.
作者信息
Plaut G S
出版信息
J R Soc Med. 1987 Feb;80(2):91-3. doi: 10.1177/014107688708000210.
Abstract
Fifty-three patients with multiple sclerosis were assessed in a double-blind multicentre study for the effect of amatadine. The patients were observed in general practices for up to four years. Relapses occurred in 5 of the 24 patients treated with amantadine and in 14 of the 29 placebo-treated patients. Neurological deterioration was not significantly different in the two groups.
摘要
在一项双盲多中心研究中，对53例多发性硬化症患者评估了金刚烷胺的疗效。这些患者在全科医疗中接受了长达四年的观察。接受金刚烷胺治疗的24例患者中有5例复发，接受安慰剂治疗的29例患者中有14例复发。两组的神经功能恶化情况无显著差异。
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