使用酚妥拉明和罂粟碱海绵体内自我注射治疗阳痿。

Intracavernous self-injection with phentolamine and papaverine for the treatment of impotence.

作者信息

Gasser T C, Roach R M, Larsen E H, Madsen P O, Bruskewitz R C

出版信息

J Urol. 1987 Apr;137(4):678-80. doi: 10.1016/s0022-5347(17)44172-3.

Abstract

To evaluate the efficacy and safety of intracavernous self-injection of phentolamine and papaverine for the treatment of impotence, 30 patients were enrolled in a prospective, randomized, double-blind, placebo-controlled cross-over study of papaverine and phentolamine versus normal saline. A total of 29 patients completed the study. The phentolamine plus papaverine combination resulted in erection in 24 patients (82.8 per cent) and no erection occurred after injection of saline. Of the patients 12 (41.4 per cent) experienced technical difficulties with the injection. Ecchymosis of the penis at the site of injection was common and 1 patient experienced priapism that resolved spontaneously. No other side effects occurred. Intracavernous self-injection with phentolamine and papaverine appears to be a safe and effective treatment of impotence but long-term effects must be determined.

摘要

为评估酚妥拉明和罂粟碱海绵体内自我注射治疗阳痿的疗效和安全性，30例患者参与了一项前瞻性、随机、双盲、安慰剂对照的罂粟碱和酚妥拉明与生理盐水对比的交叉研究。共有29例患者完成了该研究。酚妥拉明加罂粟碱联合用药使24例患者（82.8%）勃起，注射生理盐水后无勃起发生。12例患者（41.4%）注射时出现技术困难。注射部位阴茎瘀斑常见，1例患者发生阴茎异常勃起但自行缓解。未出现其他副作用。酚妥拉明和罂粟碱海绵体内自我注射似乎是一种安全有效的阳痿治疗方法，但长期效果有待确定。