Dubé Michael D, Rothfusz Christopher A, Emara Ahmed K, Hadad Matthew, Surace Peter, Krebs Viktor E, Molloy Robert M, Piuzzi Nicolas S
Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, 44195, USA.
Curr Rev Musculoskelet Med. 2022 Aug;15(4):311-322. doi: 10.1007/s12178-022-09762-7. Epub 2022 May 3.
8.5 to 50% of total joint arthroplasty (TJA) patients are reported to have preoperative malnutrition. The narrative review identifies the relationship between preoperative malnutrition for TJA patients and postoperative outcomes as well as the use of perioperative nutritional intervention to improve postoperative complications.
Biochemical/laboratory, anthropometric, and clinical measures have been widely used to identify preoperative nutritional deficiency. Specifically, serum albumin is the most prevalent used marker in TJA because it has been proven to be correlated with protein-energy malnutrition due to the surgical stress response. However, there remains a sustained incidence of preoperative malnutrition in total knee arthroplasty (TKA) and total hip arthroplasty (THA) patients due to a lack of agreement among the available nutritional screening tools and utilization of isolated laboratory, anthropometric, and clinical variables. Previous investigations have also suggested preoperative malnutrition to be a prognostic indicator of complications in general, cardiac, vascular, and orthopaedic surgery specialties. Serum albumin, prealbumin, transferrin, and total lymphocyte count (TLC) can be used to identify at-risk patients. It is important to employ these markers in the preoperative setting because malnourished TKA and THA patients have shown to have worse postoperative outcomes including prolonged length, increased reoperation rates, increased infection rates, and increased mortality rates. Although benefits from high-protein and high-anti-inflammatory diets have been exhibited, additional research is needed to confirm the use of perioperative nutritional intervention as an appropriate treatment for preoperative TJA patients.
据报道,8.5%至50%的全关节置换术(TJA)患者术前存在营养不良。本叙述性综述确定了TJA患者术前营养不良与术后结局之间的关系,以及围手术期营养干预对改善术后并发症的作用。
生化/实验室、人体测量和临床指标已被广泛用于识别术前营养缺乏。具体而言,血清白蛋白是TJA中最常用的标志物,因为它已被证明与手术应激反应导致的蛋白质能量营养不良相关。然而,由于现有营养筛查工具之间缺乏一致性,以及孤立地使用实验室、人体测量和临床变量,全膝关节置换术(TKA)和全髋关节置换术(THA)患者术前营养不良的发生率仍然居高不下。先前的研究还表明,术前营养不良总体上是普通外科、心脏外科、血管外科和骨科手术并发症的预后指标。血清白蛋白、前白蛋白、转铁蛋白和总淋巴细胞计数(TLC)可用于识别高危患者。在术前使用这些标志物很重要,因为营养不良的TKA和THA患者术后结局较差,包括住院时间延长、再次手术率增加、感染率增加和死亡率增加。尽管高蛋白和高抗炎饮食已显示出益处,但仍需要更多研究来证实围手术期营养干预作为术前TJA患者的适当治疗方法的有效性。