Qu Peng, Cheng Kaili, Gao Qi, Li Yan, Wang Minghua
Department of Neurology, The Fifth Affiliated Hospital of Harbin Medical University, Harbin, China.
Evid Based Complement Alternat Med. 2022 Apr 23;2022:4025965. doi: 10.1155/2022/4025965. eCollection 2022.
To evaluate the application value of combined detection of serum homocysteine (Hcy), Toll-like receptor 4 (TLR4), and C-reactive protein (CRP) in the diagnosis of cerebral small vessel disease (CSVD).
90 patients with CSVD admitted to our hospital within the past year were identified as the research subjects, and the patients with cognitive dysfunction were assigned to the experimental group, and those with normal cognitive function were assigned to the control group according to the evaluation of cognitive dysfunction by the Montreal Cognitive Assessment (MoCA), with 45 cases in each group.
The experimental group obtained remarkably elevated Hcy levels than the control group ( < 0.05). The patient's cognitive dysfunction is mainly attributed to the impact of serum Hcy. TLR4 and Hcy were negatively correlated with MoCA scores ( > 0.05). In comparison with the control group, the experimental group had significantly higher levels of Hcy, serum CRP, and interleukin (IL)-6 ( < 0.05).
The combined detection of serum Hcy, TLR4, and CRP features a high clinical value in the diagnosis of CSVD, which contributes to the prevention and treatment of cognitive dysfunction in patients.
评估血清同型半胱氨酸（Hcy）、Toll样受体4（TLR4）及C反应蛋白（CRP）联合检测在脑小血管病（CSVD）诊断中的应用价值。
选取我院过去一年内收治的90例CSVD患者作为研究对象，根据蒙特利尔认知评估量表（MoCA）对认知功能的评估，将存在认知功能障碍的患者纳入实验组，认知功能正常的患者纳入对照组，每组各45例。
实验组Hcy水平显著高于对照组（<0.05）。患者的认知功能障碍主要归因于血清Hcy的影响。TLR4和Hcy与MoCA评分呈负相关（>0.05）。与对照组相比，实验组Hcy、血清CRP及白细胞介素（IL）-6水平显著更高（<0.05）。
血清Hcy、TLR4及CRP联合检测在CSVD诊断中具有较高的临床价值，有助于患者认知功能障碍的防治。
