From the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Department of Accounting Information, Aletheia University, New Taipei City, Taiwan R.O.C.
Ann Plast Surg. 2022 Aug 1;89(2):214-217. doi: 10.1097/SAP.0000000000003206. Epub 2022 Apr 20.
Oral propranolol can effectively activate and accelerate infantile hemangioma (IH) involution; however, could the final outcome of oral propranolol treatment for IHs commensurate that of spontaneous involution?
This study aimed to investigate the long-term therapeutic effect of oral propranolol for IHs.
We present an individual matching comparative study with (1) oral propranolol therapy for mixed and deep IHs on the lips, nose, and parotid and (2) lesion type- and lesion location-matched untreated IHs as controls. Patients' follow-up photographs were assessed by 3 surgeons blinded of their treatment. Outcome measures were the quantification of the degree of sequelae ranging from 1 to 4 and the age at which IH achieved involution arrest.
Ten groups of oral propranolol and untreated patients with matched lesions were assessed. Average age at which lesions stabilized and reached no change in appearance was 1.7 years old and 6.3 years old for propranolol group and untreated group ( t = 5.663, P < 0.001). There was no significant difference in the quantified degree of sequelae for oral propranolol group and untreated group upon follow-up (1.60 vs 1.40, respectively; t = 1.259, P = 0.240).
Oral propranolol therapy accelerates IH involution but does not have a superior effect than spontaneous involution on the overall outcome of problematic IHs.
口服普萘洛尔可有效激活并加速婴幼儿血管瘤（IH）消退；然而，口服普萘洛尔治疗 IH 的最终结果是否与自发消退相当？
本研究旨在探讨口服普萘洛尔治疗 IH 的长期疗效。
我们进行了一项个体匹配的对比研究，（1）口服普萘洛尔治疗唇部、鼻部和腮腺混合性和深部 IH；（2）未治疗的 IH 作为对照组，与病变类型和病变位置相匹配。由 3 名对治疗不知情的外科医生对患者的随访照片进行评估。评估指标为后遗症程度（1-4 级）的量化和 IH 达到消退停止的年龄。
评估了 10 组口服普萘洛尔和未治疗的匹配病变患者。病变稳定且外观无变化的平均年龄分别为 1.7 岁和 6.3 岁（t = 5.663，P < 0.001）。在随访时，口服普萘洛尔组和未治疗组后遗症程度的量化差异无统计学意义（分别为 1.60 和 1.40；t = 1.259，P = 0.240）。
口服普萘洛尔治疗可加速 IH 消退，但在有问题的 IH 的总体结局方面，其效果并不优于自发消退。
