Sharma Vidushi, Gupta Rajeev K, Kailas Satish V, Basu Bikramjit
Laboratory for Biomaterials, Materials Research Centre, 29120Indian Institute of Science, Bangalore, India.
Centre of Excellence for Dental and Orthopedic Applications, Material Research Centre, 29120Indian Institute of Science, Bangalore, India.
J Biomater Appl. 2022 Aug;37(2):204-218. doi: 10.1177/08853282221085633. Epub 2022 May 3.
Ultra-high molecular weight polyethylene (UHMWPE) and its derivatives have been clinically used as an acetabular liner material in total hip joint replacement (THR) over last six decades. Despite significant efforts, the longevity of UHMWPE implants is still impaired due to their compromised tribological performance, leading to osteolysis and aseptic loosening. The present study aims to critically evaluate and analyze the tribological performance, of the next generation acetabular liner material, that is, a chemically modified graphene oxide (GO) reinforced HDPE/UHMWPE (HU) bionanocomposite (HUmGO), against stainless steel (SS 316L) counterface in lubricated conditions. This work also provides a performance comparative assessment of HUmGO with respect to medical grades, UHMWPE (UC) and crosslinked UHMWPE (XL-UC). Significant attempts have been made to correlate the tribological properties (frictional behavior, wear rate, wear debris shape and size, wear mechanism) with the physicomechanical conditions (contact stresses) at sliding contact and the variation in molecular architecture of different UHMWPE materials. Additionally, an emphasis is put forward to critically anlyze the nature of lubrication regime based on the bearing characterstic parameters. HUmGO exhibited a lower COF (0.07) and specific wear rate (2.86 × 10mm/Nm) than UC and XL-UC under identical sliding conditions. The worn surfaces on HUmGO revealed the signatures of less abrasive wear and limited deformation. Based on the estimated lambda (λ) ratio and Sommerfield number, all the investigated sliding contacts exhibited boundary lubrication. Taken together, the modified GO reinforced HDPE/UHMWPE bionanocomposite can be considered as a new generation biomaterial for the fabrication of acetabular liner for hip-joint prosthesis
在过去的六十年里，超高分子量聚乙烯（UHMWPE）及其衍生物在全髋关节置换术（THR）中一直被临床用作髋臼内衬材料。尽管付出了巨大努力，但UHMWPE植入物的使用寿命仍然受到损害，因为其摩擦学性能受损，导致骨溶解和无菌性松动。本研究旨在严格评估和分析下一代髋臼内衬材料，即化学改性氧化石墨烯（GO）增强HDPE/UHMWPE（HU）生物纳米复合材料（HUmGO）在润滑条件下与不锈钢（SS 316L）配对面的摩擦学性能。这项工作还对HUmGO与医用级UHMWPE（UC）和交联UHMWPE（XL-UC）进行了性能比较评估。已经做出了重大尝试，将摩擦学性能（摩擦行为、磨损率、磨损碎屑形状和尺寸、磨损机制）与滑动接触时的物理力学条件（接触应力）以及不同UHMWPE材料的分子结构变化联系起来。此外，还强调要根据轴承特性参数严格分析润滑状态的性质。在相同的滑动条件下，HUmGO的摩擦系数（0.07）和比磨损率（2.86×10mm/Nm）低于UC和XL-UC。HUmGO的磨损表面显示出较少磨料磨损和有限变形的特征。根据估计的lambda（λ）比和索末菲数，所有研究的滑动接触都表现出边界润滑。综上所述，改性GO增强HDPE/UHMWPE生物纳米复合材料可被视为一种用于制造髋关节假体髋臼内衬的新一代生物材料。
