Ozbeyaz Nail Burak, Gokalp Gokhan, Algul Engin, Sahan Haluk Furkan, Aydinyilmaz Faruk, Guliyev Ilkin, Kalkan Kamuran
Pursaklar State Hospital, 37511Department of Cardiology Clinic, Ankara, Turkey.
University of Health Sciences, 146992Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Angiology. 2023 Feb;74(2):181-188. doi: 10.1177/00033197221099425. Epub 2022 May 3.
Contrast-induced nephropathy (CIN) is one of the most common complications associated with coronary angiography and percutaneous coronary intervention (PCI). This study evaluated the relationship between the HFPEF (obesity (H), hypertension(H), atrial fibrillation (F), pulmonary hypertension (P), an age >60 years (E), and E/e' > 9 (F)) score which is used to diagnose heart failure with preserved ejection fraction and CIN. Patients (n = 1346) who underwent PCI for acute coronary syndrome (ACS) between December 2018 and January 2021 were retrospectively included. Contrast-induced nephropathy patients had significantly higher HFPEF scores (4.10 ± 1.92 vs 2.28 ± 1.56, P < .001). In addition, the HFPEF score was found to be an independent risk factor for the development of CIN (Odd Ratio 1.633 95% CI (1.473-1.811), P < .001) together with age, diabetes mellitus, systolic pulmonary arterial pressure, and left anterior descending as an infarct-related artery. According to point biserial correlation analysis, CIN and HFPEF score have a strong correlation (r = .376, P < .001). The receiver operating characteristic curve showed the optimal cutoff value of the HFPEF score to predict the development of CIN was 2.5, with 79.8% sensitivity and 64.1% specificity. In conclusion, the HFPEF score may predict the development of CIN in patients presenting with ACS and undergoing PCI.
造影剂肾病（CIN）是冠状动脉造影和经皮冠状动脉介入治疗（PCI）相关的最常见并发症之一。本研究评估了用于诊断射血分数保留的心力衰竭的HFPEF（肥胖（H）、高血压（H）、心房颤动（F）、肺动脉高压（P）、年龄>60岁（E）和E/e'>9（F））评分与CIN之间的关系。回顾性纳入了2018年12月至2021年1月期间因急性冠状动脉综合征（ACS）接受PCI的患者（n = 1346）。造影剂肾病患者的HFPEF评分显著更高（4.10±1.92 vs 2.28±1.56，P<.001）。此外，发现HFPEF评分与年龄、糖尿病、收缩期肺动脉压以及作为梗死相关动脉的左前降支一起是CIN发生的独立危险因素（比值比1.633，95%CI（1.473 - 1.811），P<.001）。根据点二列相关分析，CIN与HFPEF评分具有强相关性（r = 0.376，P<.001）。受试者工作特征曲线显示，预测CIN发生的HFPEF评分最佳截断值为2.5，敏感性为79.8%，特异性为64.1%。总之，HFPEF评分可能预测ACS患者接受PCI时CIN的发生。
