Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, Zürich 8093, Switzerland.
Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, Zürich 8093, Switzerland.
J Am Chem Soc. 2022 May 18;144(19):8717-8724. doi: 10.1021/jacs.2c02361. Epub 2022 May 3.
Carbon dioxide (CO) impacts every aspect of life, and numerous sensing technologies have been established to detect and monitor this ubiquitous molecule. However, its selective sensing at the molecular level remains an unmet challenge, despite the tremendous potential of such an approach for understanding this molecule's role in complex environments. In this work, we introduce a unique class of selective fluorescent carbon dioxide molecular sensors (CarboSen) that addresses these existing challenges through an activity-based approach. Besides the design, synthesis, and evaluation of these small molecules as CO sensors, we demonstrate their utility by tailoring their reactivity and optical properties, allowing their use in a broad spectrum of multidisciplinary applications, including atmospheric sensing, chemical reaction monitoring, enzymology, and live-cell imaging. Collectively, these results showcase the potential of CarboSen sensors as broadly applicable tools to monitor and visualize carbon dioxide across multiple disciplines.
二氧化碳（CO）影响着生活的方方面面，已经建立了许多传感技术来检测和监测这种无处不在的分子。然而，尽管这种方法在理解这种分子在复杂环境中的作用方面具有巨大的潜力，但在分子水平上对其进行选择性检测仍然是一个未满足的挑战。在这项工作中，我们通过基于活性的方法引入了一类独特的选择性荧光二氧化碳分子传感器（CarboSen），以解决这些现有挑战。除了作为 CO 传感器对这些小分子的设计、合成和评估外，我们还通过调整它们的反应性和光学性质来展示它们的实用性，使其能够在包括大气传感、化学反应监测、酶学和活细胞成像在内的广泛的多学科应用中使用。总的来说，这些结果展示了 CarboSen 传感器作为跨多个学科监测和可视化二氧化碳的广泛应用工具的潜力。
