Sahu A, Kalra S P
Life Sci. 1987 Mar 23;40(12):1201-6. doi: 10.1016/0024-3205(87)90239-6.
Delta sleep inducing peptide (DSIP) has been shown to increase sleep in various animals and it is found in various parts of the brain including the hypothalamus. While intraventricular administration of DSIP (2 or 10 micrograms) failed to affect LH release in ovariectomized rats, in two separate experiments DSIP (2 or 10; 15 or 30 micrograms) promptly stimulated LH release in ovariectomized estrogen, progesterone-primed rats. However, DSIP (10(-8) or 10(-6)M) had no effect on either basal or luteinizing hormone-releasing hormone-induced in vitro LH release from the hemipituitaries of ovarian steroid-primed rats. These findings are in accord with the hypothesis that DSIP or DSIP-like peptide(s) may activate the hypothalamic neural circuitry responsible for stimulation of LH release reported to occur during sleep.
δ睡眠诱导肽（DSIP）已被证明能增加多种动物的睡眠时间，且在包括下丘脑在内的大脑不同部位均有发现。虽然向去卵巢大鼠脑室内注射DSIP（2或10微克）未能影响促黄体生成素（LH）的释放，但在两项独立实验中，DSIP（2或10；15或30微克）能迅速刺激经雌激素、孕激素预处理的去卵巢大鼠释放LH。然而，DSIP（10^(-8)或10^(-6)M）对卵巢类固醇预处理大鼠半脑垂体基础状态下或促性腺激素释放激素诱导的体外LH释放均无影响。这些发现与以下假设一致，即DSIP或类DSIP肽可能激活下丘脑神经回路，该神经回路负责刺激据报道在睡眠期间发生的LH释放。
