Brenner Erica J, Long Millie D, Kappelman Michael D, Zhang Xian, Sandler Robert S, Barnes Edward L
Department of Pediatric Gastroenterology, University of North Carolina, 333 S. Columbia Street, 247 MacNider Hall, CB# 7229, Chapel Hill, NC, 27599, USA.
Department of Gastroenterology, University of North Carolina, 130 Mason Farm Rd, Bioinformatics Building, Suite 4143, Chapel Hill, NC, 27514, USA.
Dig Dis Sci. 2023 Jan;68(1):58-64. doi: 10.1007/s10620-022-07517-5. Epub 2022 May 3.
Medication adherence impacts disease control in inflammatory bowel disease (IBD). Existing adherence measures such as the Morisky Medication Adherence Scale 8 are often costly, non-medication-specific, and time-consuming.
We aimed to develop a non-proprietary, IBD-specific medication adherence instrument and to assess reasons for suboptimal medication adherence.
We developed the IBD Medication Adherence Tool to assess frequency of adherence and indications for missed or delayed medication doses. We co-administered the IBD Medication Adherence Tool and the Morisky Medication Adherence Scale 8 (licensed for use) to participants enrolled in an internet-based cohort of adults with IBD and taking least one daily, oral IBD medication. We used Spearman's correlation to evaluate associations between the IBD Medication Adherence Tool and Morisky Medication Adherence Scale 8. We then categorized patients as sub-optimally adherent (IBD Medication Adherence Tool score 1-4) and highly adherent (score 5) and evaluated factors associated with and reasons for suboptimal adherence using multivariable analysis.
We evaluated 514 patients (73% female, mean age 49), of whom 21.4% had suboptimal adherence. IBD Medication Adherence Tool scores were moderately correlated with Morisky Medication Adherence Scale 8 (r = 0.56, p < 0.001). The most commonly reported reasons for suboptimal adherence were forgetting, feeling well, and cost. Younger age and current smoking were associated with suboptimal adherence.
We developed a non-proprietary, IBD-specific tool to assess adherence to IBD medications, validated in a cohort of patients with IBD on daily, oral medications. Common reasons for suboptimal IBD medication adherence include forgetting, feeling well, and cost.
药物依从性影响炎症性肠病（IBD）的疾病控制。现有的依从性测量方法，如莫利斯基药物依从性量表8，通常成本高昂、非药物特异性且耗时。
我们旨在开发一种非专利的、针对IBD的药物依从性工具，并评估药物依从性欠佳的原因。
我们开发了IBD药物依从性工具，以评估依从频率以及漏服或延迟服药剂量的指征。我们将IBD药物依从性工具与莫利斯基药物依从性量表8（已获使用许可）共同施用于参与基于互联网的IBD成年患者队列且每天至少服用一种口服IBD药物的参与者。我们使用斯皮尔曼相关性来评估IBD药物依从性工具与莫利斯基药物依从性量表8之间的关联。然后，我们将患者分为依从性欠佳组（IBD药物依从性工具得分1 - 4）和高度依从组（得分5），并使用多变量分析评估与依从性欠佳相关的因素及原因。
我们评估了514名患者（73%为女性，平均年龄49岁），其中21.4%的患者依从性欠佳。IBD药物依从性工具得分与莫利斯基药物依从性量表8呈中度相关（r = 0.56，p < 0.001）。最常报告的依从性欠佳原因是遗忘、感觉良好和费用。年龄较小和当前吸烟与依从性欠佳相关。
我们开发了一种非专利的、针对IBD的工具来评估IBD药物的依从性，该工具在一组每日服用口服药物的IBD患者队列中得到验证。IBD药物依从性欠佳的常见原因包括遗忘、感觉良好和费用。
