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全髋关节置换术(THA)和全膝关节置换术(TKA)后的结局与邻里特征有关吗?来自大型医疗系统数据库的研究结果。

Are Neighborhood Characteristics Associated With Outcomes After THA and TKA? Findings From a Large Healthcare System Database.

作者信息

Adelani Muyibat A, Marx Christine M, Humble Sarah

机构信息

SSM Medical Group, St. Louis, MO, USA.

Washington University School of Medicine, Department of Surgery, Division of Public Health Sciences, St. Louis, MO, USA.

出版信息

Clin Orthop Relat Res. 2023 Feb 1;481(2):226-235. doi: 10.1097/CORR.0000000000002222. Epub 2022 May 3.

DOI:10.1097/CORR.0000000000002222
PMID:35503679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9831171/
Abstract

BACKGROUND

Non-White patients have higher rates of discharge to an extended care facility, hospital readmission, and emergency department use after primary THA and TKA. The reasons for this are unknown. Place of residence, which can vary by race, has been linked to poorer healthcare outcomes for people with many health conditions. However, the potential relationship between place of residence and disparities in these joint arthroplasty outcomes is unclear.

QUESTIONS/PURPOSES: (1) Are neighborhood-level characteristics, including racial composition, marital proportions, residential vacancy, educational attainment, employment proportions, overall deprivation, access to medical care, and rurality associated with an increased risk of discharge to a facility, readmission, and emergency department use after elective THA and TKA? (2) Are the associations between neighborhood-level characteristics and discharge to a facility, readmission, and emergency department use the same among White and Black patients undergoing elective THA and TKA?

METHODS

Between 2007 and 2018, 34,008 records of elective primary THA or TKA for osteoarthritis, rheumatoid arthritis, or avascular necrosis in a regional healthcare system were identified. After exclusions for unicompartmental arthroplasty, bilateral surgery, concomitant procedures, inability to geocode a residential address, duplicate records, and deaths, 21,689 patients remained. Ninety-seven percent of patients in this cohort self-identified as either White or Black, so the remaining 659 patients were excluded due to small sample size. This left 21,030 total patients for analysis. Discharge destination, readmissions within 90 days of surgery, and emergency department visits within 90 days were identified. Each patient's street address was linked to neighborhood characteristics from the American Community Survey and Area Deprivation Index. A multilevel, multivariable logistic regression analysis was used to model each outcome of interest, controlling for clinical and individual sociodemographic factors and allowing for clustering at the neighborhood level. The models were then duplicated with the addition of neighborhood characteristics to determine the association between neighborhood-level factors and each outcome. The linear predictors from each of these models were used to determine the predicted risk of each outcome, with and without neighborhood characteristics, and divided into tenths. The change in predicted risk tenths based on the model containing neighborhood characteristics was compared to that without neighborhood characteristics.The change in predicted risk tenth for each outcome was stratified by race.

RESULTS

After controlling for age, sex, insurance type, surgery type, and comorbidities, we found that an increase of one SD of neighborhood unemployment (odds ratio 1.26 [95% confidence interval 1.17 to 1.36]; p < 0.001) was associated with an increased likelihood of discharge to a facility, whereas an increase of one SD in proportions of residents receiving public assistance (OR 0.92 [95% CI 0.86 to 0.98]; p = 0.008), living below the poverty level (OR 0.82 [95% CI 0.74 to 0.91]; p < 0.001), and being married (OR 0.80 [95% CI 0.71 to 0.89]; p < 0.001) was associated with a decreased likelihood of discharge to a facility. Residence in areas one SD above mean neighborhood unemployment (OR 1.12 [95% CI [1.04 to 1.21]; p = 0.002) was associated with increased rates of readmission. An increase of one SD in residents receiving food stamps (OR 0.83 [95% CI 0.75 to 093]; p = 0.001), being married (OR 0.89 [95% CI 0.80 to 0.99]; p = 0.03), and being older than 65 years (OR 0.93 [95% CI 0.88 to 0.98]; p = 0.01) was associated with a decreased likelihood of readmission. A one SD increase in the percentage of Black residents (OR 1.11 [95% CI 1.00 to 1.22]; p = 0.04) and unemployed residents (OR 1.15 [95% CI 1.05 to 1.26]; p = 0.003) was associated with a higher likelihood of emergency department use. Living in a medically underserved area (OR 0.82 [95% CI 0.68 to 0.97]; p = 0.02), a neighborhood one SD above the mean of individuals using food stamps (OR 0.81 [95% CI 0.70 to 0.93]; p = 0.004), and a neighborhood with an increasing percentage of individuals older than 65 years (OR 0.90 [95% CI 0.83 to 0.96]; p = 0.002) were associated with a lower likelihood of emergency department use. With the addition of neighborhood characteristics, the risk prediction tenths of the overall cohort remained the same in more than 50% of patients for all three outcomes of interest. When stratified by race, neighborhood characteristics increased the predicted risk for 55% of Black patients for readmission compared with 17% of White patients (p < 0.001). The predicted risk tenth increased for 60% of Black patients for emergency department use compared with 21% for White patients (p < 0.001).

CONCLUSION

These results can be used to identify high-risk patients who might benefit from preemptive interventions to avoid these particular outcomes and to create more realistic, comprehensive risk adjustment models for value-based care programs. Additionally, this study demonstrates that neighborhood characteristics are associated with greater risk for these outcomes among Black patients compared with White patients. Further studies should consider that race/ethnicity and neighborhood characteristics may not function independently from each other. Understanding this link between race and place of residence is essential for future racial disparities research.

LEVEL OF EVIDENCE

Level III, therapeutic study.

摘要

背景

非白人患者在初次全髋关节置换术(THA)和全膝关节置换术(TKA)后,入住长期护理机构、再次入院以及前往急诊科就诊的比例更高。其原因尚不清楚。居住地点可能因种族而异,对于患有多种健康状况的人来说,居住地点与较差的医疗保健结果有关。然而,居住地点与这些关节置换术结果差异之间的潜在关系尚不清楚。

问题/目的:(1)邻里层面的特征,包括种族构成、婚姻比例、住宅空置率、教育程度、就业比例、总体贫困程度、获得医疗服务的机会以及乡村性,是否与择期THA和TKA后入住机构、再次入院以及前往急诊科就诊的风险增加相关?(2)在接受择期THA和TKA的白人和黑人患者中,邻里层面特征与入住机构、再次入院以及前往急诊科就诊之间的关联是否相同?

方法

在2007年至2018年期间,在一个区域医疗系统中识别出34008例因骨关节炎、类风湿性关节炎或缺血性坏死而行择期初次THA或TKA的记录。排除单髁关节置换术、双侧手术、同期手术、无法对居住地址进行地理编码、重复记录以及死亡病例后,剩余21689例患者。该队列中97%的患者自我认定为白人或黑人,因此其余659例患者因样本量小而被排除。最终留下21030例患者进行分析。确定出院目的地、术后90天内的再次入院情况以及术后90天内的急诊科就诊情况。将每位患者的街道地址与美国社区调查和地区贫困指数中的邻里特征相关联。采用多水平、多变量逻辑回归分析对每个感兴趣的结果进行建模,控制临床和个体社会人口学因素,并考虑邻里层面的聚类情况。然后在模型中加入邻里特征进行复制,以确定邻里层面因素与每个结果之间的关联。这些模型中的每个线性预测因子用于确定有无邻里特征时每个结果的预测风险,并分为十分位数。将包含邻里特征的模型的预测风险十分位数变化与不包含邻里特征的模型进行比较。每个结果的预测风险十分位数变化按种族分层。

结果

在控制年龄、性别、保险类型、手术类型和合并症后,我们发现邻里失业率每增加一个标准差(优势比1.26 [95%置信区间1.17至1.36];p < 0.001)与入住机构的可能性增加相关,而接受公共援助的居民比例增加一个标准差(OR 0.92 [95% CI 0.86至0.98];p = 0.008)、生活在贫困线以下的居民比例增加一个标准差(OR 0.82 [95% CI 0.74至0.91];p < 0.001)以及已婚居民比例增加一个标准差(OR 0.80 [95% CI 0.71至0.89];p < 0.001)与入住机构的可能性降低相关。居住在邻里失业率高于平均水平一个标准差的地区(OR 1.12 [95% CI [1.04至1.21];p = 0.0)与再次入院率增加相关。接受食品券的居民比例增加一个标准差(OR 0.83 [95% CI 0.75至093];p = 0.001)、已婚(OR 0.89 [95% CI 0.80至0.99];p = 0.03)以及年龄大于65岁(OR 0.93 [95% CI 0.88至0.98];p = 0.01)与再次入院可能性降低相关。黑人居民百分比增加一个标准差(OR 1.11 [95% CI 1.00至1.22];p = 0.04)和失业居民百分比增加一个标准差(OR 1.15 [95% CI 1.05至1.26];p = 0.003)与前往急诊科就诊的可能性更高相关。生活在医疗服务不足地区(OR 0.82 [95% CI 0.68至0.97];p = 0.02)、邻里食品券使用者比例高于平均水平一个标准差(OR 0.81 [95% CI 0.70至0.93];p = 0.004)以及65岁以上居民百分比不断增加的邻里(OR 0.90 [95% CI 0.83至0.96];p = 0.002)与前往急诊科就诊的可能性较低相关。加入邻里特征后,在所有三个感兴趣的结果中,超过50%的患者总体队列的风险预测十分位数保持不变。按种族分层时,邻里特征使55%的黑人患者再次入院的预测风险增加,而白人患者为17%(p < 0.001)。60%的黑人患者前往急诊科就诊的预测风险十分位数增加,而白人患者为21%(p < 0.001)。

结论

这些结果可用于识别可能从预防性干预中受益以避免这些特定结果的高危患者,并为基于价值的医疗计划创建更现实、全面的风险调整模型。此外,本研究表明,与白人患者相比,邻里特征与黑人患者这些结果的更高风险相关。进一步的研究应考虑种族/族裔和邻里特征可能并非相互独立起作用。理解种族与居住地点之间的这种联系对于未来的种族差异研究至关重要。

证据水平

III级,治疗性研究。

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