Hsieh S D, Iwamoto Y, Matsuda A, Kuzuya T
Metabolism. 1987 Apr;36(4):384-7. doi: 10.1016/0026-0495(87)90212-5.
Pancreatic beta-cell secretion after oral glucose or intravenous glucagon stimulation was studied in newly diagnosed patients with non-insulin-dependent diabetes mellitus (NIDDM) before and after glycemic control by diet treatment alone. Insulin secretion to oral glucose showed significant improvement, while C-peptide release by glucagon showed no significant difference before and after diet treatment. The finding suggests that pancreatic beta-cell response to oral glucose varies with different metabolic states, but this is not so after glucagon stimulation in NIDDM patients.
在仅通过饮食治疗实现血糖控制前后，对新诊断的非胰岛素依赖型糖尿病（NIDDM）患者口服葡萄糖或静脉注射胰高血糖素刺激后的胰腺β细胞分泌情况进行了研究。口服葡萄糖后的胰岛素分泌有显著改善，而饮食治疗前后胰高血糖素刺激后的C肽释放无显著差异。这一发现表明，胰腺β细胞对口服葡萄糖的反应随不同代谢状态而变化，但在NIDDM患者中，胰高血糖素刺激后并非如此。
