Department of General Pathology, Dental School, University of São Paulo, São Paulo, Brazil.
Laboratory of Medical Investigations-06, Medical School, Tropical Medicine Institute, University of São Paulo, São Paulo, Brazil ; and.
Am J Dermatopathol. 2022 Sep 1;44(9):669-674. doi: 10.1097/DAD.0000000000002221. Epub 2022 May 4.
Oral cavity is not a common route for metastatic dissemination; metastasis to the oral region may affect soft tissues and jawbones, accounting for approximately 1% of all oral malignant neoplasms. The diagnosis of metastatic lesions to the oral cavity is usually challenging to clinicians and pathologists because of their complexity and rarity. We present a series of 12 metastatic neoplasms to the oral cavity that were detected previously or after the diagnosis of the primary tumor. All tumors were of epithelial origin with primary sites in the esophagus (2 cases), colon (2 cases), bladder, lungs, liver, larynx, skin, uterus, prostate, and adrenal gland, each with one case. The commonest site of the metastatic masses in the oral cavity was the gingiva, frequently presented as a vegetating, friable mass. The clinical examination and histopathologic analysis of the lesions were central to establishing the final diagnosis of the tumors. Metastatic masses to the oral cavity should always be considered as differential diagnosis of benign-looking lesions, especially in patients with previous history of a malignant disease. Biopsy is mandatory to establish an accurate diagnosis.
口腔并非常见的转移播散途径；口腔部位的转移可能影响软组织和颌骨，占所有口腔恶性肿瘤的约 1%。由于转移病变的复杂性和罕见性，口腔转移瘤的诊断通常对临床医生和病理学家具有挑战性。我们展示了一系列 12 例先前或在原发性肿瘤诊断后发生于口腔的转移瘤。所有肿瘤均来源于上皮组织，其原发性部位分别在食管（2 例）、结肠（2 例）、膀胱、肺、肝、喉、皮肤、子宫、前列腺和肾上腺，各有 1 例。口腔转移瘤块最常见的部位是牙龈，常表现为有蒂、易碎的肿块。病变的临床检查和组织病理学分析是确定肿瘤最终诊断的关键。口腔转移瘤块应始终被视为外观良性病变的鉴别诊断，尤其是在有恶性疾病既往史的患者中。为了做出准确诊断，必须进行活检。
