Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China.
Org Biomol Chem. 2022 May 18;20(19):3930-3939. doi: 10.1039/d2ob00516f.
A series of indole-fused scaffolds and derivatives was synthesized the cyclization reaction of 2-indolylmethanols with azonaphthalene. These reactions were realized under mild reaction conditions through catalyst control, providing structurally diverse indole derivatives with moderate to excellent yields. This protocol also shows good substrate adaptability, especially in six-membered ring products.
一系列吲哚稠合骨架和衍生物是通过 2-吲哚甲醇与氮萘的环化反应合成的。这些反应在温和的反应条件下通过催化剂控制来实现，提供了结构多样的吲哚衍生物，产率中等至优秀。该方案还表现出良好的底物适应性，特别是在六元环产物中。
