Department of Neurosurgery, Dongyang People's Hospital, Jinhua, P. R. China.
Department of Neurosurgery, Dongyang People's Hospital, Jinhua, P. R. China.
World Neurosurg. 2022 Sep;165:e30-e42. doi: 10.1016/j.wneu.2022.04.113. Epub 2022 Apr 30.
To study the incidence and prognostic factors of patients with benign pituitary tumors based on the Surveillance, Epidemiology, and End Results (SEER) database.
This was a retrospective cohort study. Patients with benign pituitary tumors reported in the Surveillance, Epidemiology, and End Results database from 2004 to 2016, who presented completed demographic and clinical data, were included in our study. The age-adjusted incidence rate was calculated and stratified by year at diagnosis, age, gender, and the pathological type of benign pituitary tumor. We used Kaplan-Meier curves and multivariable Cox regressions to determine the factors associated with overall survival.
A total of 29,967 patients were included in the study, of whom 26,691 (89.07%) survived and 3276 (10.93%) died. The age-adjusted incidence rate increased from 3.15 per 100,000 person-years in 2004 to 4.66 per 100,000 person-years in 2011 (annual percent change = 5.51, P < 0.001), and the subsequent growth trend from 2011 to 2016 was not statistically significant (annual percent change = 0.26, P = 0.711). Most patients were female, aged 60-79 years, and pituitary adenomas accounted for the main proportion of the incidence of benign pituitary tumors. Surgery was associated with the overall survival on the multivariable Cox regression model (hazard ratio = 0.677, 95% confidential interval: 0.629-0.727) and Kaplan-Meier curves, especially in pituitary adenoma. Radiation was not associated with the overall survival of benign pituitary tumor.
The overall incidence of benign pituitary tumors was low but showed an increasing trend. Surgery may be beneficial to the prognosis. It should be noted that benign pituitary tumors may not require excessive treatment, such as radiation.
基于监测、流行病学和最终结果（SEER）数据库研究良性垂体瘤患者的发病率和预后因素。
这是一项回顾性队列研究。纳入 2004 年至 2016 年 SEER 数据库中报告的良性垂体瘤患者，这些患者提供了完整的人口统计学和临床数据。计算了年龄校正发病率，并按诊断年份、年龄、性别和良性垂体瘤的病理类型进行分层。我们使用 Kaplan-Meier 曲线和多变量 Cox 回归来确定与总生存率相关的因素。
共纳入 29967 例患者，其中 26691 例（89.07%）存活，3276 例（10.93%）死亡。年龄校正发病率从 2004 年的每 100000 人年 3.15 例上升到 2011 年的每 100000 人年 4.66 例（年变化率为 5.51%，P < 0.001），而 2011 年至 2016 年的增长趋势无统计学意义（年变化率为 0.26%，P = 0.711）。大多数患者为女性，年龄 60-79 岁，垂体腺瘤占良性垂体瘤发病率的主要比例。多变量 Cox 回归模型和 Kaplan-Meier 曲线显示手术与总生存率相关（风险比=0.677，95%置信区间：0.629-0.727），尤其是在垂体腺瘤中。放疗与良性垂体瘤的总生存率无关。
良性垂体瘤的总体发病率较低，但呈上升趋势。手术可能对预后有益。值得注意的是，良性垂体瘤可能不需要过度治疗，如放疗。
