通过α-氨基酰化调节用于生物成像的BODIPY的物理化学性质。
Tuning the Physicochemical Properties of BODIPY for Bioimaging via -Amino Acylation.
作者信息
Shi Wei, Li Jie, He Xinyu, Zhou Siming, Sun Hongbao, Wu Haoxing
机构信息
Huaxi MR Research Center, Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Org Lett. 2022 May 13;24(18):3368-3372. doi: 10.1021/acs.orglett.2c01118. Epub 2022 May 3.
A series of BODIPY probes with a wide emission range were prepared via aminoacylation at the -position. Functional moieties were also introduced to induce bathochromic shifts in emission, improve water solubility, increase Stokes shifts, and construct bioorthogonal turn-on probes. The developed analogues were successfully used in live-cell imaging, suggesting that the described strategy can be used to prepare probes with improved bioimaging potential.
通过在β位进行氨酰化反应制备了一系列发射范围较宽的BODIPY探针。还引入了功能基团以诱导发射光谱红移、提高水溶性、增加斯托克斯位移并构建生物正交开启型探针。所开发的类似物成功用于活细胞成像，表明所描述的策略可用于制备具有改善的生物成像潜力的探针。
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