Department of Cardiology of Wuhan, No.1 Hospital, No. 215 Zhongshan Avenue, Wuhan, 430022, Hubei Province, China.
J Cardiothorac Surg. 2022 May 3;17(1):94. doi: 10.1186/s13019-022-01848-0.
Diabetes and impaired glucose regulation are very common in patients with coronary artery disease (CAD). In this study, we aim to investigate the prevalence of abnormal glucose regulation in men and women in Chinese CAD patients.
In this retrospective study, 4100 patients (male, n = 2873; female, n = 1227)with CAD were enrolled. The mean age of these patients was 63 years. The demographic data, medical history, echocardiography findings and blood investigations were collected and analyzed.
In this population, 953 (24%) patients had definite diagnosis of type 2 diabetes mellitus, including 636 males (23%) and 317 females (27%). There was a higher prevalence of diabetes in females than men (p < 0.05). For the remaining patients, 48% (n = 959) undergone an oral glucose tolerance test (OGTT), which revealed that 83 male patients (12%) and 41 female patients (16%) suffered from the type 2 diabetes (p > 0.05). 283 men (40%) and 105 women (41%) had impaired glucose regulation (IGR) (p > 0.05). Only 338 men (25%) and 109 women (19%) showed the normal glucose regulation, implying a higher prevalence of abnormal glucose regulation in females (p < 0.01). The odd ratio (OR) showed that women were more prone to have diabetes mellitus or IGT than men and the OR was 1.44 and 1.43 respectively.
Abnormal glucose regulation is highly prevalent in CAD patients. The women are more prone to have diabetes mellitus or IGT than men.
糖尿病和葡萄糖调节受损在冠心病（CAD）患者中非常常见。在本研究中，我们旨在研究中国 CAD 患者中男性和女性异常葡萄糖调节的患病率。
在这项回顾性研究中，共纳入 4100 例 CAD 患者（男性，n=2873；女性，n=1227）。这些患者的平均年龄为 63 岁。收集并分析了他们的人口统计学数据、病史、超声心动图结果和血液检查结果。
在该人群中，有 953 例（24%）患者被明确诊断为 2 型糖尿病，其中 636 例男性（23%）和 317 例女性（27%）。女性的糖尿病患病率高于男性（p<0.05）。对于其余患者，48%（n=959）进行了口服葡萄糖耐量试验（OGTT），结果显示 83 例男性患者（12%）和 41 例女性患者（16%）患有 2 型糖尿病（p>0.05）。283 例男性（40%）和 105 例女性（41%）存在葡萄糖调节受损（IGR）（p>0.05）。仅有 338 例男性（25%）和 109 例女性（19%）表现出正常葡萄糖调节，这意味着女性异常葡萄糖调节的患病率更高（p<0.01）。比值比（OR）显示，女性患糖尿病或 IGT 的可能性高于男性，OR 分别为 1.44 和 1.43。
异常葡萄糖调节在 CAD 患者中非常普遍。女性比男性更容易患有糖尿病或 IGT。
