• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
ACE2 trials suggest remodeling, not dilation, as primary therapeutic effect.血管紧张素转换酶2（ACE2）试验表明，主要治疗效果是重塑而非扩张。
Pulm Circ. 2022 Jan 20;12(1):e12022. doi: 10.1002/pul2.12022. eCollection 2022 Jan.
2
Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction.血管紧张素转换酶2的缺失会加速心肌梗死后适应性不良的左心室重塑。
Circ Heart Fail. 2009 Sep;2(5):446-55. doi: 10.1161/CIRCHEARTFAILURE.108.840124. Epub 2009 Jun 15.
3
ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction.在大鼠心肌梗死模型中，血管紧张素转换酶 2（ACE2）过表达可改善左心室重构和功能障碍。
Hum Gene Ther. 2010 Nov;21(11):1545-54. doi: 10.1089/hum.2009.160.
4
Angiotensin-converting enzyme 2 is a critical determinant of angiotensin II-induced loss of vascular smooth muscle cells and adverse vascular remodeling.血管紧张素转换酶 2 是血管紧张素 II 诱导的血管平滑肌细胞丢失和血管不良重塑的关键决定因素。
Hypertension. 2014 Jul;64(1):157-64. doi: 10.1161/HYPERTENSIONAHA.114.03388. Epub 2014 May 5.
5
The angiotensin converting enzyme 2/angiotensin-(1-7)/Mas Receptor axis as a key player in alveolar bone remodeling.血管紧张素转换酶 2/血管紧张素-(1-7)/Mas 受体轴作为肺泡骨重塑的关键因素。
Bone. 2019 Nov;128:115041. doi: 10.1016/j.bone.2019.115041. Epub 2019 Aug 20.
6
Angiotensin-converting enzyme 2 activation suppresses pulmonary vascular remodeling by inducing apoptosis through the Hippo signaling pathway in rats with pulmonary arterial hypertension.血管紧张素转换酶 2 激活通过 Hippo 信号通路诱导细胞凋亡抑制肺动脉高压大鼠肺血管重构。
Clin Exp Hypertens. 2019;41(6):589-598. doi: 10.1080/10641963.2019.1583247. Epub 2019 Feb 26.
7
Atrial overexpression of angiotensin-converting enzyme 2 improves the canine rapid atrial pacing-induced structural and electrical remodeling. Fan, ACE2 improves atrial substrate remodeling.血管紧张素转换酶2在心房的过表达可改善犬快速心房起搏诱导的结构和电重构。范，血管紧张素转换酶2可改善心房基质重构。
Basic Res Cardiol. 2015;110(4):45. doi: 10.1007/s00395-015-0499-0. Epub 2015 Jul 5.
8
Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy.血管紧张素转换酶 2 过表达改善糖尿病心肌病大鼠模型的左心室重构和功能。
J Am Coll Cardiol. 2012 Feb 21;59(8):739-47. doi: 10.1016/j.jacc.2011.09.071.
9
[Angiotensin-converting enzyme 2 particapates in ozone-induced lung inflammation and airway remodeling in mice].[血管紧张素转换酶2参与臭氧诱导的小鼠肺部炎症和气道重塑]
Nan Fang Yi Ke Da Xue Xue Bao. 2022 Jun 20;42(6):860-867. doi: 10.12122/j.issn.1673-4254.2022.06.09.
10
Tsantan Sumtang attenuated chronic hypoxia-induced right ventricular structure remodeling and fibrosis by equilibrating local ACE-AngII-AT1R/ACE2-Ang1-7-Mas axis in rat.丹参酮通过平衡大鼠局部 ACE-AngII-AT1R/ACE2-Ang1-7-Mas 轴减轻慢性低氧诱导的右心室结构重塑和纤维化。
J Ethnopharmacol. 2020 Mar 25;250:112470. doi: 10.1016/j.jep.2019.112470. Epub 2019 Dec 17.

本文引用的文献

1
Renin-Angiotensin-Aldosterone System Inhibitor Use and Mortality in Pulmonary Hypertension: Insights From the Veterans Affairs Clinical Assessment Reporting and Tracking Database.肾素-血管紧张素-醛固酮系统抑制剂在肺动脉高压患者中的应用与死亡率：来自退伍军人事务部临床评估报告和跟踪数据库的见解。
Chest. 2021 Apr;159(4):1586-1597. doi: 10.1016/j.chest.2020.09.258. Epub 2020 Oct 5.
2
MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension.MDM2 介导的血管紧张素转换酶 2 泛素化参与肺动脉高压的发生。
Circulation. 2020 Sep 22;142(12):1190-1204. doi: 10.1161/CIRCULATIONAHA.120.048191. Epub 2020 Jul 28.
3
A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension.血管紧张素转化酶 2 在人类肺动脉高压中的潜在治疗作用。
Eur Respir J. 2018 Jun 21;51(6). doi: 10.1183/13993003.02638-2017. Print 2018 Jun.
4
Recombinant angiotensin-converting enzyme 2 suppresses pulmonary vasoconstriction in acute hypoxia.重组血管紧张素转换酶2可抑制急性低氧时的肺血管收缩。
Wilderness Environ Med. 2012 Mar;23(1):24-30. doi: 10.1016/j.wem.2011.09.002.
5
Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension.Bmpr2 相关肺动脉高压中的细胞骨架缺陷。
Am J Physiol Lung Cell Mol Physiol. 2012 Mar 1;302(5):L474-84. doi: 10.1152/ajplung.00202.2011. Epub 2011 Dec 16.
6
Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension.血管紧张素转换酶2作为预防肺动脉高压治疗靶点的证据。
Am J Respir Crit Care Med. 2009 Jun 1;179(11):1048-54. doi: 10.1164/rccm.200811-1678OC. Epub 2009 Feb 26.
7
Mas oncogene signaling and transformation require the small GTP-binding protein Rac.原癌基因信号传导和转化需要小GTP结合蛋白Rac。
Mol Cell Biol. 1998 Mar;18(3):1225-35. doi: 10.1128/MCB.18.3.1225.
8
Role of angiotensin-converting enzyme and angiotensin II in development of hypoxic pulmonary hypertension.血管紧张素转换酶和血管紧张素II在缺氧性肺动脉高压发展中的作用。
Am J Physiol. 1995 Oct;269(4 Pt 2):H1186-94. doi: 10.1152/ajpheart.1995.269.4.H1186.
9
Haemodynamic and hormonal effects of captopril in primary pulmonary hypertension.卡托普利对原发性肺动脉高压的血流动力学和激素影响
Br Heart J. 1982 Dec;48(6):541-5. doi: 10.1136/hrt.48.6.541.
10
Short- and long-term hemodynamic effects of captopril in patients with pulmonary hypertension and selected connective tissue disease.
Chest. 1992 Nov;102(5):1407-12. doi: 10.1378/chest.102.5.1407.

ACE2 trials suggest remodeling, not dilation, as primary therapeutic effect.

作者信息

West James

机构信息

Vanderbilt University Nashville Tennessee USA.

出版信息

Pulm Circ. 2022 Jan 20;12(1):e12022. doi: 10.1002/pul2.12022. eCollection 2022 Jan.

DOI:10.1002/pul2.12022
PMID:35506063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9053010/
Abstract
摘要