Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI, 30200, Bagnols-sur-Cèze, France.
Service d'Accueil des urgences, CHU de Nîmes, 30029, Nîmes, France.
Environ Microbiol. 2022 Sep;24(9):4299-4316. doi: 10.1111/1462-2920.16028. Epub 2022 May 9.
Since the beginning of the pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the gastrointestinal (GI) tract has emerged as an important organ influencing the propensity to and potentially the severity of the related COVID-19 disease. However, the contribution of the SARS-CoV-2 intestinal infection on COVID-19 pathogenesis remains to be clarified. In this exploratory study, we highlighted a possible link between alterations in the composition of the gut microbiota and the levels of SARS-CoV-2 RNA in the gastrointestinal tract, which could be more important than the presence of SARS-CoV-2 in the respiratory tract, COVID-19 severity and GI symptoms. As established by metaproteomics, altered molecular functions in the microbiota profiles of high SARS-CoV-2 RNA level faeces highlight mechanisms such as inflammation-induced enterocyte damage, increased intestinal permeability and activation of immune response that may contribute to vicious cycles. Uncovering the role of this gut microbiota dysbiosis could drive the investigation of alternative therapeutic strategies to favour the clearance of the virus and potentially mitigate the effect of the SARS-CoV-2 infection.
自严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引发的大流行开始以来，胃肠道 (GI) 已成为影响相关 COVID-19 疾病易感性和潜在严重程度的重要器官。然而，SARS-CoV-2 肠道感染对 COVID-19 发病机制的贡献仍有待阐明。在这项探索性研究中，我们强调了肠道微生物组组成的变化与胃肠道中 SARS-CoV-2 RNA 水平之间可能存在的联系，这可能比呼吸道中存在 SARS-CoV-2、COVID-19 严重程度和胃肠道症状更为重要。通过代谢蛋白质组学确定，高 SARS-CoV-2 RNA 水平粪便中微生物组谱的改变分子功能突出了炎症诱导的肠细胞损伤、肠道通透性增加和免疫反应激活等机制，这些机制可能导致恶性循环。揭示这种肠道微生物失调的作用可能会推动对替代治疗策略的研究，以促进病毒清除，并有可能减轻 SARS-CoV-2 感染的影响。
