Obstetrics and Gynecology Unit, Mother-Infant and Adult Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
International Doctorate School in Clinical and Experimental Medicine, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.
Gynecol Endocrinol. 2022 Jun;38(6):483-487. doi: 10.1080/09513590.2022.2069747. Epub 2022 May 4.
Among risk factors for SB, maternal endocrine diseases (ED), such as thyroids dysfunction and gestational diabetes mellitus (GDM), are the most frequent. This study aimed to investigate the rate of ED in a population of SB cases collected prospectively, and the relationship between these and causes of death.
This is an area-based, prospective cohort study conducted in Emilia-Romagna, Italy between January 2014 and December 2020. Data included all cases of SB (>22 weeks).
From 2014 to 2020, 766 SB occurred out of a total of 232.506 births (SB rate:0.3/1000). The ED were present in 197/766 cases of SB (25.7%), respectively, 104 thyroid disease (52.8%), 74 GDM (37.5%), and 19 cases of concomitant GDM and thyroid disease (9.6%). Women who had SB associated with ED presented significantly higher mean maternal age ( < 0.001), BMI ( < 0.001), obesity ( < 0.001) and lower smoking habit ( = 0.02) respect with control group. Neonatal and placental weight of stillborn women with ED was significantly higher ( < 0.001) in respect to stillborn of the control group. Women with ED as associated condition (ReCODE classification), present significantly higher cases of SB caused by placenta pathologies ( = 0.009) namely abruptio placentae ( = 0.001) respect than control group.
ED was more frequent in older and obese women experiencing SB. The main cause of death was abruptio placentae. This information can be helpful when counseling mothers with ED and planning antenatal management to prevent SB.
在 SB 的风险因素中，母体内分泌疾病（ED），如甲状腺功能障碍和妊娠期糖尿病（GDM）最为常见。本研究旨在调查前瞻性收集的 SB 病例中 ED 的发生率，以及这些 ED 与死亡原因之间的关系。
这是一项在意大利艾米利亚-罗马涅地区进行的基于人群的前瞻性队列研究，时间为 2014 年 1 月至 2020 年 12 月。数据包括所有 SB（>22 周）病例。
2014 年至 2020 年，共有 766 例 SB 发生于 232506 例分娩中（SB 发生率：0.3/1000）。在 766 例 SB 病例中，ED 分别为 197 例（25.7%），分别为 104 例甲状腺疾病（52.8%）、74 例 GDM（37.5%）和 19 例 GDM 和甲状腺疾病并存（9.6%）。患有 ED 的 SB 女性的平均母亲年龄（ < 0.001）、BMI（ < 0.001）、肥胖（ < 0.001）更高，吸烟习惯（ = 0.02）更低，与对照组相比。患有 ED 的死产女性的新生儿和胎盘重量明显高于（ < 0.001）对照组的死产女性。作为合并症（ReCODE 分类）的 ED 女性，患有胎盘疾病导致的 SB 病例明显更高（ = 0.009），即胎盘早剥（ = 0.001），与对照组相比。
ED 在经历 SB 的老年和肥胖女性中更为常见。主要死亡原因是胎盘早剥。这些信息在为 ED 母亲提供咨询和计划产前管理以预防 SB 时可能会有所帮助。
