Dawson A M
Gut. 1978 Jun;19(6):504-9. doi: 10.1136/gut.19.6.504.
Disturbance of ammonia metabolism is an important but not the only factor in the genesis of hepatic coma. In this review mechanisms controlling the concentration of ammonia in the blood other than disturbed liver function have been discussed. The key function of ammonia in the pyridine nucleotide cyde has been outlined and it is suggested that the function of this cycle in patients with liver disease would repay further study.
氨代谢紊乱是肝昏迷发生的一个重要因素,但并非唯一因素。在这篇综述中,讨论了除肝功能紊乱外控制血氨浓度的机制。概述了氨在吡啶核苷酸循环中的关键作用,并提出该循环在肝病患者中的功能值得进一步研究。