School of First Clinical, Henan University of Chinese Medicine, Zhengzhou, 450000, China.
Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, China.
Chin J Integr Med. 2022 Aug;28(8):753-761. doi: 10.1007/s11655-022-3513-4. Epub 2022 May 4.
Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) is an intracellular sensor that detects endogenous danger signals and environmental irritants to assemble into the NLRP3 inflammasome. Activation of the NLRP3 inflammasome leads to the secretion of the proinflammatory cytokines interleutkin (IL)-1β and IL-18 and induces pyroptosis. Recent studies have shown that the NLRP3 inflammasome participates in the initiation and progression of diabetic atherosclerosis through pathological mechanisms such as β-cell dysfunction, insulin resistance, endothelial cell dysfunction, monocyte adhesion and infiltration, and smooth muscle cell proliferation and migration. In diabetic atherosclerosis, Chinese medicine has been proven effective for the inflammatory response mediated by the NLRP3 inflammasome. This review summarizes the latest progress on the NLRP3 inflammasome in the pathogenesis and potential Chinese medicine treatment of diabetic atherosclerosis.
核苷酸结合寡聚化结构域样受体家族富含pyrin 结构域蛋白 3（NLRP3）是一种细胞内传感器，可检测内源性危险信号和环境刺激物，从而组装成 NLRP3 炎性体。NLRP3 炎性体的激活导致促炎细胞因子白细胞介素（IL）-1β和 IL-18 的分泌，并诱导细胞焦亡。最近的研究表明，NLRP3 炎性体通过β细胞功能障碍、胰岛素抵抗、内皮细胞功能障碍、单核细胞黏附和浸润以及平滑肌细胞增殖和迁移等病理机制参与糖尿病动脉粥样硬化的发生和发展。在糖尿病性动脉粥样硬化中，中药已被证明可有效抑制 NLRP3 炎性体介导的炎症反应。本综述总结了 NLRP3 炎性体在糖尿病性动脉粥样硬化发病机制及潜在的中药治疗方面的最新进展。
