Network of Immunity in Infection, Malignancy, and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Isfahan, Iran.
School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mini Rev Med Chem. 2022;22(20):2624-2640. doi: 10.2174/1389557522666220504135853.
N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors, highly important in regulating substantial physiologic processes in the brain and the nervous system, and disturbance in their function could contribute to different pathologies. Overstimulation and hyperactivity of NMDARs, termed glutamate toxicity, could promote cell death and apoptosis. Meanwhile, their blockade could lead to dysfunction of the brain and nervous system. A growing body of evidence has demonstrated the prominent role of NMDARs in demyelinating disorders and anti- NMDAR encephalitis. Herein, we provide an overview of NMDARs' dysfunction in the physiopathology of demyelinating disorders such as multiple sclerosis and neuromyelitis optica spectrum disorders.
N-甲基-D-天冬氨酸受体（NMDARs）是离子型谷氨酸受体，在调节大脑和神经系统的重要生理过程中起着至关重要的作用，其功能障碍可能导致不同的病理。NMDAR 的过度刺激和过度活跃，称为谷氨酸毒性，可能会促进细胞死亡和细胞凋亡。同时，其阻断可能导致大脑和神经系统功能障碍。越来越多的证据表明 NMDAR 在脱髓鞘疾病和抗 NMDAR 脑炎中起重要作用。在此，我们概述了 NMDAR 在多发性硬化症和视神经脊髓炎谱系疾病等脱髓鞘疾病的病理生理学中的功能障碍。
